Possible Effect of Natural Honey on Isoproterenol Induced Acute Myocardial Infarction in Adult Male Albino Rats

Abstract

Acute myocardial infarction (AMI) is the main cause of death worldwide [1]. It is the acute condition of necrosis of the myocardium that occurs due to an imbalance between myocardial demands coronary blood supplies [2]. The accumulations of free radicals have been implicated in the pathophysiology of AMI [2]. Ischemia occurring during AMI is a potential cause of increased free radicals [3]. Myocardial injury in rat was induced using Isoproterenol (ISO), a synthetic β-adrenergic agonist, as a result of causing disturbance in the balance between production of free radicals and antioxidative defense system [4]. Honey, a natural liquid produced by honey bees, has received a considerable attention recently because it contains different substances that are believed to have a therapeutic role in cardiovascular diseases [5]. Materials and Methods Materials