Binder syndrome complicating pregnancy. Report of three cases and mini review of the literature

Abstract

According to recent bibliography,prenatal diagnosis reflects meticulous depiction of imaging findings in order to establish proper therapeutic mapping of potential congenital malformations. Predisposition factors such as age of the mother, absence or hypoplasia of nasal bone, increased NT (nuchal translucency) measurement, heredity, gene disorders are strongly accompanied with congenital deviations. Sonographic imaging findings of fetal facial anatomic area can provide information concerning antenatal diagnosis of fetuses with various congenital syndromes and chromosomal aberrations. Deviation from normal proportions of fetal facial profile not only might consist of ‘soft sonographic signs’ , leading to important clues, but also suggests presence of chromosomal disorders. Binder Syndrome is characterized by midfacial hypoplasia, associated with absence of nasal spine, leading to a flat profile and depressed nasal bridge. Aim of our study consists prenatal presentation of rare case series of Binder Syndrome , proper diagnosed and assiduous treated.