Evaluation of anti-obesity activity of Garuga pinnata Roxb. in high fat diet induced rats

Abstract

Objective : The objective of the present study was to evaluate the Anti-obesity activity of Garuga pinnata Roxb in high fat diet induced rats. Materials and Methods: Gall part of leaves of Garuga pinnata were collected, dried, powdered and extracted with ethanol (70%) to get Ethanolic extract of Garuga pinnata (EGP). Rats were divided into 5 groups in high fat diet induced model. Normal control animals were fed with the rat chow diet and all other grouped rats were fed with high fat diet, Standard group was treated with Orlistat (10 mg/kg, p.o.) and rats of test groups were treated with the EGP (100 and 200 mg/kg, p.o.) for 4 weeks. Anthropometric parameters were measured once in a week and lipid profile and antioxidant parameters were measured on the 29 th day. Histopathology of kidney and liver was studied. Results: Body weight and BMI was significantly reduced in the test groups (100 and 200 mg/kg, p.o.). TG, TC, LDL-C, VLDL-C, LPO levels were reduced and HDL-C and anti-oxidants were elevated in both test groups as compare to disease control animals. Histopathology of liver showed protection against fat accumulation in Ethanolic extract of Garuga pinnata (100 and 200 mg/kg, p.o.). Conclusion: In the light of finding and discussion, it was concluded that Ethanolic extract of Garuga pinnata (100 and 200 mg/kg) may have anti-obesity in high fat diet induced rats and showed preventive effect against fat accumulation in liver.