Role of Nigella sativa oil and Alpha lipoic acid on Amikacin induced hepatorenal toxicity in rabbits

A. Zohree, A. M. Abdelmoteleb, O. Hamed
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Abstract

A mikacin (AK) has long been used as an effective antibiotic to prevent Gram-negative infections. Despite its numerous benefits, Amikacin has considerable hepato-renal toxic adverse effects. The potential preventive benefits of NSO, “Nigella sativa oil” and/or ALA, “Alpha lipoic acid” were investigated in rabbits with Amikacin-induced acute hepa-to- renal injury. Rabbits were treated with AK (100mg/kg BW/day I/M in-jection) alone or with NSO (2ml/kg BW orally) and /or ALA (50 mg/kg BW/day) daily for seven days. Serum biochemical parameters well as tissue oxidative stress indicators were measured to evaluatehepato-renal damage. Rabbits administered AK showed substantial changes in serum biochemical hepato-renal damage indicators with reduction in tissue antioxidant bi-omarkers and rise in hepato-renal oxidant. NSO plus ALA treatment potentially alleviated the AK induced changes in blood and tissue biochemistry. The current study
黑草油和α硫辛酸对阿米卡星致家兔肝肾毒性的作用
米卡星(AK)长期以来一直被用作预防革兰氏阴性感染的有效抗生素。尽管阿米卡星有许多好处,但它有相当大的肝肾毒性副作用。研究了NSO、“黑草油”和/或ALA、“α硫辛酸”对阿米卡辛诱导的急性肝肾损伤兔的潜在预防作用。兔分别单独给予AK (100mg/kg BW/day注射I/M)或与NSO (2ml/kg BW口服)和/或ALA (50mg /kg BW/day)治疗,连续7天。测定血清生化指标及组织氧化应激指标评价肝肾损害。给药家兔血清生化肝肾损伤指标发生显著变化,组织抗氧化双标记物降低,肝肾氧化剂升高。NSO + ALA治疗可能减轻AK诱导的血液和组织生化变化。目前的研究
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