Células madre y progenitoras para la reparación de cartílago articular

Revista Latinoamericana de Cirugía Ortopédica Pub Date : 2016-04-01 DOI:10.1016/j.rslaot.2016.10.002

Francisco Rodriguez-Fontan , Jorge Chahla , Nicolas S. Piuzzi , Karin Payne , George F. Muschler , Robert F. LaPrade , Cecilia Pascual-Garrido

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引用次数: 3

Abstract

Cartilage is a sensitive tissue prone to damage with the continuous practice of sports and ageing process, holding a low self repairing capacity. Degenerative joint diseases are among the most disabling and limiting in regards to life quality and daily activities. Biological therapies have become available to potentially treat osteoarthritis and focal chondral defects. However, there is still no efficient way to regenerate native hyaline cartilage. Stem cell therapy and bioengineering is a promising field which can transform the paradigms in orthopaedics. This review provides an overall view of the current state of biological therapies with stem and progenitor cells. We summarize cell therapy options with culture expanded cells and also four common sources of adult stem cells: bone marrow, adipose tissue, synovium and peripheral venous blood, along with clinical studies reporting their effectiveness. The purpose of this review is to summarize adult stem cells approaches for the treatment of focal chondral lesions and osteoarthritis.

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软骨是一种敏感组织，随着运动的不断练习和老化过程，容易受到损伤，自我修复能力较低。退行性关节疾病在生活质量和日常活动方面是最致残和限制的。生物疗法已成为治疗骨关节炎和局灶性软骨缺损的潜在手段。然而，目前还没有有效的方法来再生天然透明软骨。干细胞治疗和生物工程是一个很有前途的领域，可以改变骨科的范式。本文综述了干细胞和祖细胞生物治疗的现状。我们总结了培养扩增细胞的细胞治疗选择，以及四种常见的成体干细胞来源:骨髓、脂肪组织、滑膜和外周静脉血，以及报告其有效性的临床研究。本综述的目的是总结成体干细胞治疗局灶性软骨病变和骨关节炎的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista Latinoamericana de Cirugía Ortopédica

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