CA125 serum levels in Correlation with Preeclampsia severity

Abstract

Back ground: PET a disease of theories of unknown particular cause characterized by hypertensive disorder, protein excretion in urine that additionally could be accompanied or not by organ dysfunction. CA125 is an antigen measured by radioimmunoassay. Its physiological and molecular significance in obstetric diseases is not fully clarified most research trials are made on this antigen in obstetric research field to explore and investigate its role as a marker in various diseases. Aim: The current research was performed to evaluate and correlate the correlation between CA125 serum level in normal gestations and gestations affected by PET. Methodology: The current research study is composed of 300 singleton gestations. The study subjects were divided into 3 research groups: control research group (n = 100), mild PET research group (n = 100) and severe PET research group (n = 100). The three research groups were statistically alike as regards variables such as maternal age, gestational age and BMI.The research study was conducted at a private hospital in Jeddah, KSA, United Doctors Hospital. over 3 years from April 2014 to April 2017. Results: The current research study results displayed that no statistical significant difference existed between the research study groups concerning age, BMI, parity, smoking, GA and serum creatinine. On the other hand SBP, DBP, serum urea, serum CA125, urine protein, and NICU admission were statistically significantly lowest in control research group followed by mild PET research group and statistically significantly highest in severe PET research group. Interestingly it has been revealed in the current research findings that platelets count was statistically significantly lowest in severe PET research group with no statistically significant difference between control and mild groups. The current research study have evaluated in addition diagnostic performance of laboratory investigations performed between research study groups displayed the following Serum BUN, serum CA125 and proteinuria had statistically significant high diagnostic performance and features in discriminating between PET from normal (highest in urine protein).On the other hand Serum BUN had statistically significant moderate diagnostic performance and features , whereas serum CA125 and urine protein had statistically significant high diagnostic performance and features in discriminating severe from mild PET (highest in urine protein). Conclusion: Our research group came to the conclusion that serum CA125 level in maternal serum is directly correlated to PET presence and its degree of severity i.e CA-125 is a Biological marker mirroring the disease severity .Additionally it has the privilege of being. More readily available and considered less costly in comparison to other biological markers, It could be used as a screening tool for PET. However larger sample size should be considered in future research studies and consideration should be made for ethnic and racial difference that could aid in future met analysis performance.