Individualized surgical treatment in patients with advanced gastrointestinal stromal tumor — a case series

IF 0.3 Q4 ONCOLOGY
Jakub Pytlos, J. Pałucki, M. Lenarcik, Ireneusz Pierzankowski, A. Klimczak, T. Olesiński
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引用次数: 0

Abstract

In this case series we present the cases of two patients at a metastatic stage of stomach gastrointestinal stromal tumor, who received treatment with imatinib. After a period of disease stability patients showed signs of resistance to the first-line therapy and despite the promising switch to sunitinib, developed life-threatening complications. Salvage surgeries were performed, aimed at preserving patients life and simultaneously reducing the tumor mass. Operation greatly improved patients condition and allowed for successful continuation of tyrosine kinase inhibitor treatment, showing that surgery should be considered a viable complement to the chemotherapeutical treatment.
晚期胃肠间质瘤个体化手术治疗-病例系列
在这个病例系列中,我们提出了两个转移期胃胃肠道间质瘤患者的病例,他们接受了伊马替尼治疗。在一段时间的疾病稳定后,患者表现出对一线治疗的耐药迹象,尽管有希望改用舒尼替尼,但仍出现了危及生命的并发症。进行挽救性手术,目的是挽救患者的生命,同时减少肿瘤的体积。手术极大地改善了患者的病情,并允许酪氨酸激酶抑制剂治疗的成功延续,表明手术应被认为是化疗治疗的可行补充。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.90
自引率
20.00%
发文量
46
审稿时长
15 weeks
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