Pharmacological efficiency of combined eye drug films based on Levofloxacin and Dexpanthenol, and also Dexamethazone and Dexpanthenol in the treatment of infected corneal injury

M. Medvedeva, V. Lipatov, M. Zatolokina, Oksana M. Yarmamedova
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Abstract

Background: When treating infected corneal burns, some patients are not able to comply with the schedule of frequent instillations of drugs, which entails a persistent irreversible decrease in visual acuity due to the formation of corneal opacities. The aim of the study: To increase the effectiveness of treatment of infected corneal burns using combined ophthalmic medicinal films based on Levofloxacin and Dexpanthenol, as well as Dexamethasone and Dexpanthenol. Materials and methods: 1 hour after the formation of a standard infected corneal burn, the comparison group was treated according to the classical method using instillations, and the experimental group was treated with combined ophthalmic medicinal films based on Levofloxacin and Dexpanthenol, as well as Dexamethasone and Dexpanthenol. The area of the defect in the corneal epithelium was recorded. Morphological examination with hematoxylin-eosin staining was carried out according to the standard technique at different periods of observation. Results: A pronounced cellular reaction was recorded already 1 hour after the formation of a standard infected corneal burn. The defect area of the corneal epithelium decreased faster in the group treated with combined ophthalmic drug films. The thickness of the outer corОригинальная статья Original article Ярмамедов ДМ, и др. Фармакологическая эффективность ... Yarmamedov DM, et al. Pharmacological efficiency of combined eye ... 390 neal epithelium, as well as the number of cells in its layers, returned to normal on the 3rd day in the experimental group, and in the comparison group with treatment according to the standard method on the 5th day of the experiment. When examining the thickness of the corneal endothelium, there were no statistically significant differences from the normal cornea. Conclusion: In the treatment of a standard infected corneal burn, the use of combined ophthalmic medicinal films can reduce the process of morphological restoration of the cornea to 3 days, in comparison with treatment using instillations, where the cornea is restored to the parameters of an intact eye on the 5th day.
左氧氟沙星、右潘醇联合眼药膜及地塞米松、右潘醇联合眼药膜治疗感染性角膜损伤的药理效果
背景:在治疗感染性角膜烧伤时,一些患者不能遵守频繁滴注药物的时间表,导致角膜混浊形成,导致视力持续不可逆下降。目的:探讨以左氧氟沙星和右泛醇为基础的联合眼药膜以及地塞米松和右泛醇治疗感染性角膜烧伤的疗效。材料与方法:标准角膜感染烧伤形成1小时后,对照组按经典方法滴注治疗,实验组采用以左氧氟沙星、右泛醇、地塞米松、右泛醇为基础的联合眼药膜治疗。记录角膜上皮缺损面积。在观察的不同时期,按标准技术进行苏木精-伊红染色形态学检查。结果:在标准感染角膜烧伤形成1小时后,已记录到明显的细胞反应。联合用药组角膜上皮缺损面积减小较快。外层的厚度和Оригинальнаястать原始文章ЯярмамедовДМ,идр。Фармакологическая эффективность…Yarmamedov DM,等。联合眼的药理疗效…实验组390只,各层细胞数在实验第3天恢复正常,对照组在实验第5天按标准方法处理。角膜内皮厚度与正常角膜比较,差异无统计学意义。结论:在标准的感染性角膜烧伤治疗中,使用联合眼药膜治疗可将角膜形态恢复过程缩短至3天,而使用滴注治疗则在第5天角膜恢复到完整眼的参数。
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