Thyroid Functions in Children on Levetiracetam or Valproic Acid Therapy

IF 0.2 Q4 PEDIATRICS

Journal of Pediatric Epilepsy Pub Date : 2020-11-02 DOI:10.1055/s-0040-1716916

Elif Karatoprak, Samet Paksoy

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引用次数: 1

Abstract

Abstract The aim of this study was to investigate the thyroid functions in children receiving levetiracetam or valproate monotherapy. We retrospectively reviewed the records of children with controlled epilepsy receiving valproic acid (VPA group) or levetiracetam monotherapy (LEV group) for at least 6 months. Free thyroxine 4 levels (fT4) and thyroid stimulating hormone (TSH) levels were compared between VPA group, LEV group, and age- and gender-matched healthy children (control group). A total of 190 children were included in the study: 63 were in the VPA, 60 in the LEV, and 67 in the control group. Although there was no significant difference regarding average fT4 levels, higher TSH levels were found in the VPA group when compared with the LEV and control groups (p < 0.001 and p < 0.001, respectively). There was no significant difference in terms of fT4 and TSH values in the LEV group when compared with the control group (p = 0.56 and p = 0.61, respectively). Subclinical hypothyroidism (defined as a TSH level above 5 uIU/mL with a normal fT4 level was detected in 16% of patients in the VPA group, none in the LEV and control groups. Our study found that VPA therapy is associated with an increased risk of subclinical hypothyroidism while LEV had no effect on thyroid function tests.

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左乙拉西坦或丙戊酸治疗对儿童甲状腺功能的影响

摘要本研究旨在探讨左乙拉西坦或丙戊酸单药治疗对儿童甲状腺功能的影响。我们回顾性回顾了接受丙戊酸(VPA组)或左乙拉西坦单药治疗(LEV组)至少6个月的控制癫痫患儿的记录。比较VPA组、LEV组和年龄、性别匹配的健康儿童(对照组)游离甲状腺素4 (fT4)和促甲状腺激素(TSH)水平。研究共纳入190名儿童:VPA组63名，LEV组60名，对照组67名。虽然平均fT4水平没有显著差异，但与LEV组和对照组相比，VPA组的TSH水平更高(p < 0.001和p < 0.001)。LEV组fT4和TSH值与对照组比较差异无统计学意义(p = 0.56和p = 0.61)。VPA组中16%的患者检测到亚临床甲状腺功能减退(定义为TSH水平高于5 uIU/mL, fT4水平正常)，LEV组和对照组中无。我们的研究发现VPA治疗与亚临床甲状腺功能减退的风险增加有关，而LEV对甲状腺功能测试没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Epilepsy PEDIATRICS-

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期刊介绍： The Journal of Pediatric Epilepsy is an English multidisciplinary peer-reviewed international journal publishing articles on all topics related to epilepsy and seizure disorders, epilepsy surgery, neurology, neurosurgery, and neuropsychology in childhood. These topics include the basic sciences related to the condition itself, the differential diagnosis, natural history, and epidemiology of seizures, and the investigation and practical management of epilepsy (including drug treatment, neurosurgery and non-medical and behavioral treatments). Use of model organisms and in vitro techniques relevant to epilepsy are also acceptable. Journal of Pediatric Epilepsy provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in the diagnosis and treatment of childhood epilepsy.