Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state

Abstract

Objective: This study aimed to investigate oxidative metabolism and oxidative DNA damage in the state of euthymic and active disease in patients with Bipolar disorder (BD). Methods: 40 active (26 mania and14 depression episodes) and 40 euthymic state of disease of the 80 patients with BD and 48 healthy volunteers were included to the study. Measurement of the levels of serum total antioxidant (TAS) and serum total oxidant (TOS), Oxidative Stress Index (OSI), and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels were calculated and evaluated. Hamilton Depression Rating Scale (HAM-D), Young Mania Rating Scale (YMRS) and Clinical Global Impression Scale (CGI) were administered. Results: In patients with BD, TAS, TOS, OSI, and 8-OHdG levels were significantly higher than controls (all p<0.001). TOS level significantly higher in female than men in BD (p=0.016). A significantly positive weak correlation was detected between the TAS level and CGI score (p=0.031, r=0.241), HAM-D score (p=0.040, r=0.231) in BD. When patients in the active and euthymic state were compared with the control group separately, in both groups TAS, TOS, OSI, and 8-OHdG levels were significantly higher than controls (all p<0.001). However, there was no significant difference in TOS, OSI, and 8-OHdG levels between patients in the active or euthymic state of disease. Conclusion: Oxidants and DNA damage are high in patient with BD. No difference of the oxidants and DNA damage between the active and euthymic state of disease reveals that oxidative stress damages on the body although the symptoms of the disease to quiet down. Level of Total Antioxidant, Level of Total Oxidant, Oxidative DNA Damage, 8-hydroxydeoxyguanosine