[Periodontal disease].

M. Michikawa
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Abstract

It has been shown that the inflammatory pathways are activated in the brains of patients with Alzheimer disease (AD), and the use of anti-inflammatory drugs reduces risk to develop AD. It is understood that molecules involved in this inflammation promote pathological processes leading to AD, whereas other molecules work to protect neuron/brain function from toxicity found in AD pathogenesis. Periodontal disease is one of the diseases causing inflammation and recent lines of evidence show the link between these two diseases. In this paper, relationship between periodontitis and AD will be reviewed and the possible mechanisms, by which periodontitis may affect the onset and progression of AD, will be discussed.
牙周疾病。
研究表明,阿尔茨海默病(AD)患者大脑中的炎症通路被激活,使用抗炎药物可以降低患AD的风险。据了解,参与这种炎症的分子促进了导致AD的病理过程,而其他分子则保护神经元/脑功能免受AD发病机制中发现的毒性的影响。牙周病是引起炎症的疾病之一,最近的证据表明这两种疾病之间存在联系。本文将对牙周炎与AD的关系进行综述,并对牙周炎影响AD发生和发展的可能机制进行讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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