The psoriatic keratinocytes

Abstract

Psoriasis is an inflammatory skin disease with characteristic changes in the epidermis that resembles unsuppressed wound healing due to excessive hyperproliferation of keratinocytes. The keratinocyte hyperproliferation is also accompanied by abnormal differentiation of cells. It is not clear how much keratinocytes contribute to disease pathology. In this article, the authors, however, attempt to summarize data that argue for the importance of abnormal keratinocyte behavior in the pathomechanism of psoriatic skin lesions.