Immunological reactivity in calves obtained from revaccinated cows during immunization with vaccines from B.abortus strains 19, 104M and 82

Abstract

The system of anti-brucellosis measures requires constant improvement in order to increase its effectiveness and reliability. At the same time, the priority remains the creation of high specific protection for brucellosis in animals. Live vaccines from agglutinogenic strains of B.abortus 19, 104M and 82 turned out to be the most immunogenic and effective in antiepizootic relation. As a result of the conducted studies, it was found that the most pronounced general and local reactions were noted in calves vaccinated subcutaneously with a standard dose of vaccine from strain 19, less pronounced in vaccinated with vaccine from strain 104M and weakly in vaccinated with vaccine from strain 82. According to the results of serological studies of blood serum, it can be seen that all animals (100%) reacted in calves for 10-20 days after immunization with vaccines from strains 19 and 104M, and only 40% of calves vaccinated with vaccine from strain 82 reacted. At the same time, calves vaccinated with the strain 19 vaccine reacted in RA in the titers 400-1600 ME. Vaccine from strain 104M - in titers 400-800 ME, vaccine from strain 82 - in titers 25-50 ME. According to the results of serological studies, the state of tolerance was not noted in calves received from re-immunized cows after immunization with agglutinogenic anti-brucellosis vaccines. Further study of the dynamics of antibodies after the introduction of vaccines from strains 19, 104М and 82 by subcutaneous method in a full dose to calves of 3-5 months of age received from re-vaccinated cows showed that the timing of the maximum rise and extinction of the titers of agglutinating and complement-binding antibodies in the blood serum of vaccinated animals is also directly dependent on the properties of the vaccine used. Thus, as a result of serological studies, it was found that the repeated reimunization of pregnant cows with vaccines from strains B.abortus 19, 104M and 82 have no significant effect on the immunological reactivity of the offspring obtained from them, which is confirmed by the absence of a state of tolerance in calves after immunization with agglutinogenic anti-brucellosis vaccines.