ANTHOCYANINS IN STRAWBERRY POLYPHENOLIC EXTRACT AMELIORATE METABOLIC DISTURBANCES IN RATS FED A DIET HIGH IN FAT

Abstract

In that study we tried to scrutinize the metabolic effects of two dietary strawberry polyphenolic extracts containing or not an anthocyanins fraction in rats fed high-fat diet. Forty-eight Wistar rats were fed with basal or obesogenic diet that contained two different extracts, specifically polyphenolic profile: 60/50, 35/35, 5/6 and 0/9% ellagitannins, proanthocyanidins, flavonols, and anthocyanins, in EP/EPA extracts respectively. Although both extracts beneficially affected liver and serum lipid profile (total cholesterol, HDL and HDL fractions, triglycerides), the EPA extract showed more pronounced health-promoting effects on the content of lean and fat tissues in the body (NMR analysis) as well as serum concentration of leptin, adiponectin, C-reactive protein, IL-6, and TNF-alpha. In the conclusion, the metabolic action of the extract containing anthocyanins besides other polyphenolic fractions in the normalization of dietary high-fat-induced disturbances was more distinctive than those of the extract without anthocyanins fraction. In the recent study it was also shown that dietary combination of fructooligosaccharides with EPA extract exhibited beneficial effects (versus EP preparation) in the lower gut of rats (1). Supported by the National Science Centre Poland (grant DEC-2012/05/B/NZ9/03402). (1) Fotschki B., Juskiewicz J., Jurgonski A., et al., 2016. PLOS ONE 11(2): e0149081.