A novel coated silver ketamine(I) electrode for potentiometric determination of ketamine hydrochloride in ampoules and urine samples

Analytical Chemistry Research Pub Date : 2014-11-01 DOI:10.1016/j.ancr.2014.10.003

Hazem M. Abu Shawish , Salman M. Saadeh , Hassan Tamos , Khalid I. Abed-Almonem , osama Al khalili

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引用次数: 16

Abstract

A new ketamine coated silver electrode (KCSE) based on ketamine hydrochloride with sodium tetraphenylborate (KT-TPB) as electroactive material has been described. The influence of membrane composition, type of solvent mediators, kind of electroactive materials and interfering ions on the sensor was investigated. The sensor displays Nernstian response of 55.8 ± 0.3 mV/decade over the concentration range of 2.5 × 10⁻⁶ to 1.0 × 10⁻² M with limit of detection of 8.5 × 10⁻⁷ M. The coated wire electrode has short response time ∼8 s and it can be used in pH range of 2.6–6.4. The selective coefficients were determined in relation to several inorganic, organic ions, sugars and some common drug excipients. The KCSE electrode was successfully used for the determination of the ketamine content in ampoule and urine samples with satisfactory results. Statistical student’s t-test and F test showed insignificant systematic error between proposed and official methods.

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一种新型包覆氯胺酮银电极电位法测定安瓿和尿样中盐酸氯胺酮

以四苯基硼酸钠(KT-TPB)为电活性材料，制备了一种新型氯胺酮包覆银电极(KCSE)。考察了膜组成、溶剂介质类型、电活性材料种类和干扰离子对传感器性能的影响。在2.5 × 10−6 ~ 1.0 × 10−2 M的浓度范围内，传感器的Nernstian响应为55.8±0.3 mV/ 10年，检测限为8.5 × 10−7 M。涂层丝电极的响应时间短~ 8 s，可用于2.6 ~ 6.4 pH范围。测定了几种无机离子、有机离子、糖和常用药物辅料的选择系数。KCSE电极用于安瓿和尿液样品中氯胺酮含量的测定，结果满意。统计学生t检验和F检验表明，建议方法和官方方法之间的系统误差不显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Analytical Chemistry Research

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