EFFECT OF VITAMIN D STATUS ON LIPID METABOLISM OF CHILDREN

Abstract

It has been proven that the functions of vitamin D are not limited to the control of calcium-phosphorus metabolism, but its other pleiotropic effects are being studied. The aim of our study was to study vitamin D status and its effect on the lipid profile in children of risk group for the development of dyslipoproteinemia. Materials and methods 30 children aged 6–7 years (mean age 6.4±0.6 years) who were born to women with diabetes were examined. The control group – 30 children 6–7 years old (6.5±0.5 years) from healthy mothers. An assessment of physical development was carried out with the calculation of body mass index. We studied lipid metabolism indicators - total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol (mmol / l) in blood, atherogenic index. All children were determined with the content of 25-OH-D in the serum, the level of glucose. Results 10 (33.3 %) children from mothers with diabetes are overweight, 5 (16.7 %) – obesity, which is 2 times higher than in the control group. The fasting glucose level in all the examined children from mothers with diabetes was within physiological fluctuations. The level of 25-OH-D in children from mothers with diabetes mellitus, compared with the control group, was significantly reduced. Dyslipoproteinemia was found in children from diabetic mothers: a significant increase in serum triglyceride and cholesterol levels, higher levels of low-density lipoprotein cholesterol and lower levels of high-density lipoprotein cholesterol than in the control group (p <0.05), atherogenic index was significantly higher. Prospects for further research are to explore the possibility of using vitamin D for the primary prevention and treatment of metabolic syndrome, diabetes in children. Conclusions Vitamin D deficiency in the body of the surveyed can be one of the causes of their dyslipidemia, in addition, overweight and obesity are also risk factors for the development of atherosclerosis, metabolic syndrome. Children at risk need dynamic monitoring of anthropometric indicators, control of body mass index, lipid and carbohydrate blood profile, level 25-OH-D.