Role of Serum B-type Natriuretic Peptide before and after 2hours of Spontaneous Breathing Trial among Patients under Mechanical Ventilation

Journal of Current and Advance Medical Research Pub Date : 2021-07-01 DOI:10.3329/jcamr.v8i2.57438

A. F. Hoque, M. Mazumder, Omma Hafsa Any, Sharna Moin, R. Gupta, Shahadat Hossain Polash, Rajan Mondol, Sheikh Ul Alam

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Abstract

Background: Weaning of a patient from mechanical ventilation is very important for the outcomes of the patients. Objective: The purpose of the study was to evaluate the serum level of BNP before and after 2hours of spontaneous breathing trial (SBT) among patients under mechanical ventilation. Methodology: This prospective cohort study was conducted in the Department of Anesthesia, Analgesia and Intensive Care Medicine at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh over a period of 2 years. Study population was selected for weaning from mechanical ventilation support for the first time in the age group of more than 18 years with both sexes. Plasma BNP level of all patients was measured before and after 2 hours of spontaneous breathing trial. Results: A total number of 30 patients were recruited for this study. One-third (33.3%) of the patients failed on SBT. The mean percent changes of BNP (pg/ml) during 2-h of SBT in weaning success and failure groups were 38.41±9.379 and 59.51±2.940 respectively (p=0.01). The receiver-operating characteristic curve analysis for BNP as a predictor of weaning outcome, showed that the area under the curve (AUC) was 0.89. Conclusion: In conclusion BNP is currently a good predictor of different cardiac diseases. Journal of Current and Advance Medical Research, July 2021;8(2):125-129

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机械通气患者自主呼吸试验前后血清b型利钠肽的作用

背景:患者脱离机械通气对患者的预后非常重要。目的:评价机械通气患者自主呼吸试验(SBT)前后2h血清BNP水平。方法:这项前瞻性队列研究在孟加拉国达卡的Bangabandhu Sheikh Mujib医科大学麻醉、镇痛和重症监护医学系进行，为期2年。在18岁以上的男女年龄组中首次选择脱离机械通气支持的研究人群。所有患者在自主呼吸试验前和试验后2小时均测定血浆BNP水平。结果:本研究共招募了30例患者。三分之一(33.3%)的患者SBT治疗失败。脱机成功组和脱机失败组SBT 2 h期间BNP (pg/ml)的平均变化百分比分别为38.41±9.379和59.51±2.940 (p=0.01)。接受者-工作特征曲线分析显示，BNP作为断奶结局的预测因子，曲线下面积(AUC)为0.89。结论:综上所述，BNP目前是不同心脏疾病的良好预测因子。现代与先进医学研究杂志，2021;8(2):125-129

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Journal of Current and Advance Medical Research

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