Heat shock protein-90: Independent predictor of rheumatoid arthritis-associated usual interstitial pneumonia

IF 0.2 Q4 RESPIRATORY SYSTEM
H. Assal, A. Shalaby, Samar Farrag, Asmaa Ali, I. Ibrahim, R. Elkaffas, I. Sabry
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引用次数: 0

Abstract

Background It has recently been shown that the heat shock protein (HSP) is implicated in the pathogenesis of pulmonary fibrosis. The current trial was achieved to detect the relation of HSP-90 in usual interstitial pneumonia (UIP)-associated rheumatoid arthritis (RA). Results Sixty RA patients were studied. Their mean age was 49.63 ± 9.22 years with a mean disease duration of 7.5 (2–14) years. High-resolution computed tomography (HRCT) chest was performed on all patients. Thirty four (56.6%) patients had abnormal radiological findings in CT chest and 26 (43.3%) had normal CT chest findings. In patients with pulmonary involvement by HRCT, the most common abnormality found was small airway disease in 23 (38.3%), followed by UIP in nine (15%), and rheumatoid nodules in two (3.3%) patients. Patients with UIP pattern in HRCT chest has a significant higher level of HSP-90 level in comparison with those with RA-associated small airway disease pattern, P=0.003, and in comparison with other RA patients with no pulmonary involvement by HRCT, P=0.006. Conclusions HSP-90 was significantly elevated in UIP-associated RA and hence studying its inhibition in further studies would have a promising therapeutic role in this subset of patients.
热休克蛋白90:类风湿关节炎相关的常规间质性肺炎的独立预测因子
最近有研究表明,热休克蛋白(HSP)与肺纤维化的发病机制有关。目前的试验是为了检测HSP-90与通常间质性肺炎(UIP)相关的类风湿关节炎(RA)的关系。结果本组共60例RA患者。平均年龄49.63±9.22岁,平均病程7.5(2 ~ 14)年。所有患者均行胸部高分辨率计算机断层扫描(HRCT)。34例(56.6%)胸部CT表现异常,26例(43.3%)胸部CT表现正常。在肺部受累的HRCT患者中,最常见的异常是23例(38.3%)的小气道疾病,其次是9例(15%)的UIP, 2例(3.3%)的类风湿结节。HRCT胸部UIP型患者的HSP-90水平明显高于RA相关小气道疾病型患者,P=0.003;与其他HRCT未累及肺部的RA患者相比,P=0.006。结论HSP-90在uip相关性RA中显著升高,因此进一步研究其抑制作用将对这类患者具有良好的治疗作用。
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来源期刊
自引率
0.00%
发文量
46
审稿时长
22 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.
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