Features of Lipid Metabolism and Level of Pro-inflammatory Cytokines in Patients with Type-2 Diabetes and with Diabetic Nephropathy Depending on the Stage of Chronic Kidney Disease

Abstract

Purpose: Study of the role and relationship of lipid metabolism parameters and level of pro-inflammatory cytokines in patients with type-2 diabetes with diabetic nephropathy (DN) depending on the stage of chronic kidney disease (CKD). Materials and methods: 240 patients with type-2 diabetes were examined in the early stages of DN and CKD. Results: The development of DN was accompanied by an increase in the level of pro-inflammatory cytokines and impaired lipid metabolism (hypertriglyceridemia) in patients with type 2 diabetes. A negative correlation was found between the level of triglycerides (TG) and the glomerular filtration rate (GFR) (r=-0.43) and a direct relationship between the level of IL-6 and TG (r=0.48). Findings: An increase in the level of pro-inflammatory cytokines and TG increases the risk of the development and progression of DN and CKD.