Monoclonal Antibodies: A Tool in Clinical Research

Q4 Medicine

Journal, Indian Academy of Clinical Medicine Pub Date : 2013-01-01 DOI:10.4137/IJCM.S11968

Waliza Ansar, Shyamasree Ghosh

引用次数: 34

Abstract

Monoclonal antibodies (MAbs) are an old immunological tool with applications in the fields of immunology, biotechnology, biochemistry, and applied biology. Production of monoclonal antibodies using hybridoma technology was discovered in 1975 by Georges Kohler of West Germany and Cesar Milstein of Argentina. Modern-day research on MAbs from laboratories worldwide is revealing additional applications in diverse branches of sciences. Recently, MAbs have been widely applied in the field of clinical medicine. Currently, MAbs account for one-third of all the new therapeutic treatments for breast cancer, leukemia, arthritis, transplant rejection, asthma, and psoriasis, with many more late-stage clinical trials being conducted. In this review, we outline the (i) production of MAbs, (ii) application of MAbs, (iii) antibody engineering, and (iv) pharmaceutical application of MAbs. The future prospect of this review lies in the applicability of monoclonal antibodies as a molecule for understanding and monitoring the biology of disease and its role in research, clinical, diagnostic, analytical, and pharmaceutical applications.

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单克隆抗体:临床研究的工具

单克隆抗体(mab)是一种古老的免疫学工具，在免疫学、生物技术、生物化学和应用生物学等领域有着广泛的应用。利用杂交瘤技术生产单克隆抗体是1975年由西德的Georges Kohler和阿根廷的Cesar Milstein发现的。世界各地实验室对单克隆抗体的现代研究正在揭示在不同科学分支中的其他应用。近年来，单克隆抗体已广泛应用于临床医学领域。目前，单克隆抗体占乳腺癌、白血病、关节炎、移植排斥、哮喘和牛皮癣所有新治疗方法的三分之一，还有更多的后期临床试验正在进行中。在本文中，我们概述了(i)单克隆抗体的生产，(ii)单克隆抗体的应用，(iii)抗体工程，(iv)单克隆抗体的制药应用。这篇综述的未来前景在于单克隆抗体作为一种理解和监测疾病生物学的分子的适用性及其在研究、临床、诊断、分析和制药方面的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal, Indian Academy of Clinical Medicine Medicine-Medicine (all)

CiteScore

0.10

自引率

0.00%

发文量

期刊介绍： Indian Association of Clinical Medicine is an academic body constituted in the year 1992 by a group of clinicians with the main aim of reaffirming the importance of clinical medicine in this era of high-tech diagnostic modalities. There is no doubt that modern investigational methods have contributed a lot to the present day medical practice but that does not render clinical acumen and examination less important. The art and science of clinical medicine helps up to make proper and judicious use of investigations and not these be the sole basis of our practice. That is the basic idea behind this ''Association''. We presently have members and fellows of the association from all over the country. In August, 2002 the body was registered as "Indian Association of Clinical Medicine" by the Registrar of Societies, Delhi.