SARS-CoV-2 and Nervous System - Neurological Manifestations in Patients With COVID-19: A Systematic Review

Luiz Severo Bem Junior, Pedro Lukas do Rêgo Aquino, N. Rabelo, M. A. Aquino, Ana Cristina Veiga Silva, R. Mota, H. A. Filho
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Abstract

Coronavirus (CoV) is a virus infectious disease with a considerable spectrum of clinical presentations. Symptoms ranged from asymptomatic infection to severe pneumonia that may lead to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and several clinical complications. Neurologic symptoms related to CoV have been described recently in the literature. The relationship between SARS-CoV-2 and the central nervous system (CNS) is still not clear. This review aimed to reveal the current knowledge regarding CNS manifestation in SARS-CoV-2. A systematic literature review was carried out to identify the particularities of coronavirus disease 2019 (COVID-19) in patients with CNS involvement, using the PubMed database between January 1, 2020 and April 30, 2020. Conference papers, reviews, published letters, editorials, studies in pregnant women and children, and studies only reporting on a specific factor were excluded. An initial search included as many as 83 articles. Out of the 83 screened articles, 32 were selected for full-text review. Sixteen studies were excluded because they did not analyze nervous system involvement in SARS-CoV-2 infection. Thus, 16 papers were included in this review. There were three retrospective studies and 13 case reports/series of cases. Data from the current literature reveal that patients who suffer from a severe illness have more CNS involvement, neurological symptoms (i.e., dizziness, headache) and an association with strokes. The severe patients had higher D-dimer and C-reactive protein levels than non-severe patients and presented multiple organ involvement, such as serious liver, kidney and muscle damage. J Neurol Res. 2020;10(4):113-121 doi: https://doi.org/10.14740/jnr602
SARS-CoV-2与COVID-19患者的神经系统表现:一项系统综述
冠状病毒(CoV)是一种具有广泛临床表现的病毒传染病。症状从无症状感染到可能导致严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)的严重肺炎,以及几种临床并发症。与冠状病毒相关的神经系统症状最近在文献中有所描述。SARS-CoV-2与中枢神经系统(CNS)的关系尚不清楚。本综述旨在揭示目前关于SARS-CoV-2的中枢神经系统表现的知识。利用2020年1月1日至2020年4月30日的PubMed数据库进行系统文献综述,以确定2019冠状病毒病(COVID-19)在中枢神经系统受损伤患者中的特殊性。会议论文、评论、发表的信件、社论、孕妇和儿童的研究以及仅报告特定因素的研究被排除在外。最初的搜索包括多达83篇文章。从83篇筛选文章中,选择32篇进行全文综述。16项研究被排除在外,因为它们没有分析SARS-CoV-2感染中神经系统的影响。因此,本综述共纳入16篇论文。有3项回顾性研究和13例病例报告/系列病例。目前文献的数据显示,患有严重疾病的患者有更多的中枢神经系统受累、神经系统症状(即头晕、头痛)和与中风有关。重症患者的d -二聚体和c反应蛋白水平高于非重症患者,并出现多脏器受累,如严重的肝、肾和肌肉损伤。中华神经科学杂志,2020;10(4):113-121 doi: https://doi.org/10.14740/jnr602
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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