Comparison of Curcumin and Methylprednisolone in Preventing Epidural Fibrosis After Spinal Surgery: An Experimental Study

T. Yildirim, Ali Yilmaz, S. Köktürk, H. Işık
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Abstract

Aim:We aimed to compare the effectiveness of curcumin, which has been shown to inhibit cell migration and proliferation, with that of methylprednisolone, which has been shown to have a similar mechanism of action to that of curcumin and to delay tissue repair and wound healing, in the prevention of epidural fibrosis in an experimental laminectomy model in rats.Material and methods:The experiment was conducted with 40 male Wistar rats weighing 250-300 g which were divided into four groups. Laminectomy was performed from L1 to L4 in all groups. Curcumin and methylprednisolone were applied to the other two groups except the control and Dmso groups. The vertebral colon was excised en bloc and each section was examined for epidural fibrosis formation under a light microscope to evaluate histologically using the grading system.Results:The statistical analyses indicated that the treatment groups had a significant effect on the histological grades of epidural fibrosis in rats compared to the control group.Discussion:Curcumin, derived from the rhizome (Rhizoma Curcumae) of turmeric (Curcuma longa) was found to show a significant effect in the prevention of epidural fibrosis formation with its potent antioxidant and anti-inflammatory properties and by inhibiting further recruitment of fibroblasts to the laminectomy area.Conclusions:In the present study, both histological examination and statistical analyses indicated that the administration of curcumin led to a remarkable reduction in epidural fibrosis after laminectomy.
姜黄素和甲基强的松龙预防脊柱术后硬膜外纤维化的实验研究
目的:我们的目的是比较姜黄素和甲基强的松龙在实验性椎板切除术大鼠模型中预防硬膜外纤维化的有效性,姜黄素已被证明具有抑制细胞迁移和增殖的作用,甲基强的松龙已被证明具有与姜黄素相似的作用机制,并延迟组织修复和伤口愈合。材料与方法:选取体重250 ~ 300 g的雄性Wistar大鼠40只,分为4组。所有组均从L1至L4行椎板切除术。除对照组和Dmso组外,其余两组均应用姜黄素和甲基强的松龙。椎结肠整体切除,在光镜下检查每个切片是否硬膜外纤维化形成,使用分级系统进行组织学评估。结果:统计学分析表明,与对照组相比,各治疗组对大鼠硬膜外纤维化的组织学分级有显著影响。讨论:姜黄素,来源于姜黄(姜黄)的根茎(姜黄),通过其有效的抗氧化和抗炎特性,以及通过抑制成纤维细胞进一步募集到椎板切除术区域,被发现在预防硬膜外纤维化形成方面显示出显著的效果。结论:在本研究中,组织学检查和统计分析都表明姜黄素的使用导致椎板切除术后硬膜外纤维化的显著减少。
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