The usefulness of angiopoietin-1 as biomarker in missed abortion

Abstract

Objective: To detect serum angiopoietin -1 level as effective biomarker for missed abortion in early pregnancy. Methods: The study included 100 pregnant women; 50 pregnant women with missed abortion (group A) and 50 pregnant women with viable intrauterine pregnancy in first trimester (group B). Both groups were test for serum level of angiopoietin -1 using   Enzyme linked immunosorbent assay technique. Results: The mean serum angiopoietin -1 level is significantly decrease in missed abortion compare with control group women (771.12 ± 165 VS 1381.12 ± 340.36) respectively at P value (0.001). There was correlation between missed abortion and (body mass index, reproductive history) in groups of study. Conclusion: The current study showed that serum levels of angiopoitin-1 are significantly decrease in pregnant women with missed abortion compared with its level in normal viable intrauterine pregnancy of matched gestation.