Local and Systemic Changes in the Fibrinolytic System During Gynecological Surgery and the Effect of Foy on these Changes

Abstract

We used basilic and uterine vein blood samples to study local and systemic changes in the fibrinolytic system of 30 patients undergoing gynecological surgery and evaluated the effectiveness of preoperative administration of ethyl-p- (6-guanidino hexanoyloxy) benzoate methanesulfonate (FOY) in reducing surgery related bleeding. Our results confirm that fibrinolytic activity tends to increase during gynecological surgery and also suggest that basilic vein blood is not a reliable indicator of local fibrinolytic activity. The systemic administration of 5.0 – 7.5 mg/kg FOY was found to inhibit local fibrinolytic activity during abdominal hysterectomy and no serious side effects were observed.