Research progress on the mechanism of β human papillomavirus induced cutaneous squamous cell carcinoma

Abstract

Human papillomaviruse (HPV) infects squamous epithelium and induces hyperproliferative lesions. β human papillomavirus (β-HPV) is a common type of HPV according to the nucleic acid sequence of L1 protein. In recent years, the incidence of cutaneous squamous cell carcinoma (CSCC) has increased, β-HPV may be involved in the pathogenesis of CSCC. Besides, β-HPV inhibits p53 and pRb tumor suppressor genes through virus E6 and E7 proteins, which plays an important role in the initial stage of cancer. Therefore, the β-HPV is a target for preventing CSCC, especially for patients with immunosuppression who have received organ transplantation. Key words: Neoplasms, squamous cell; Betapapillomavirus; Mechanism