Ameliorative Eefects of Tiger Nut (Cyperus esculentus) on Aluminum Chloride Induced Renal Histopathology on Adult Wistar Rats

Bayero Journal of Pure and Applied Sciences Pub Date : 2022-07-06 DOI:10.4314/bajopas.v14i2.7

A. Gudaji, M. Shuaibu, A. Idris

{"title":"Ameliorative Eefects of Tiger Nut (Cyperus esculentus) on Aluminum Chloride Induced Renal Histopathology on Adult Wistar Rats","authors":"A. Gudaji, M. Shuaibu, A. Idris","doi":"10.4314/bajopas.v14i2.7","DOIUrl":null,"url":null,"abstract":"Tiger nut (Cyperus esculentus) is known in Nigeria as aya in Hausa, “Ofio” in Yoruba and “Aki Hausa” in Igbo, is an edible perennial grass-like plant. Tiger nut tubers can be eaten snacked, roasted, fried or baked and liquid (Kunun aya). Tiger nut contain lipid, protein, and carbohydrate (fiber and starch included). Tiger nut can be used to ‘mop up’ and scavenge free-radicals generated by essential metabolic body reactions and environmental pollutants. The major route of aluminium elimination is by the kidneys.Due to its reactivity, aluminum in nature is found only in combination with other elements like chlorine as in aluminum chloride (AlCl3). Al compound are used in a variety of foodstuffs, medications, domestic water supplies, kitchen equipments. herbs and cosmetics. If the kidney cannot excrete Al, it will accumulate in the body. The aim of this work was to evaluate the protective effects of tiger nut against aluminium chloride induced renal histopathology in the kidney of wistar rats. Twenty adult males and females wistar rats weighing 80 – 170g were grouped into 4. Group 1 - Control group, received normal saline for 14 days, Group 2 – received 1250mg of liquid tiger (ethanolic extract) nut extract daily by oral route for 14days. Group 3 – received aqueous aluminium chloride 500mg/kg followed by 2500mg/kg of liquid tiger nut extract daily by oral route for 14days and Group 4 – received aqueous aluminium chloride 500mg/kg followed by 3750mg/kg of liquid tiger nut extract daily by oral route for 14days. After sacrifice and tissue processing, groups 1 and 2 presented normal renal histology while groups 3 and 4 presented normal renal histology with lymphocytes between their distal convoluted tubules around the medulla. It was concluded that tiger nut has an ameliorative effect on AlCl3 induced histomorphological changes in the histology of kidney and it has no any negative effect on the histology of kidney.","PeriodicalId":8734,"journal":{"name":"Bayero Journal of Pure and Applied Sciences","volume":"80 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bayero Journal of Pure and Applied Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/bajopas.v14i2.7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Tiger nut (Cyperus esculentus) is known in Nigeria as aya in Hausa, “Ofio” in Yoruba and “Aki Hausa” in Igbo, is an edible perennial grass-like plant. Tiger nut tubers can be eaten snacked, roasted, fried or baked and liquid (Kunun aya). Tiger nut contain lipid, protein, and carbohydrate (fiber and starch included). Tiger nut can be used to ‘mop up’ and scavenge free-radicals generated by essential metabolic body reactions and environmental pollutants. The major route of aluminium elimination is by the kidneys.Due to its reactivity, aluminum in nature is found only in combination with other elements like chlorine as in aluminum chloride (AlCl3). Al compound are used in a variety of foodstuffs, medications, domestic water supplies, kitchen equipments. herbs and cosmetics. If the kidney cannot excrete Al, it will accumulate in the body. The aim of this work was to evaluate the protective effects of tiger nut against aluminium chloride induced renal histopathology in the kidney of wistar rats. Twenty adult males and females wistar rats weighing 80 – 170g were grouped into 4. Group 1 - Control group, received normal saline for 14 days, Group 2 – received 1250mg of liquid tiger (ethanolic extract) nut extract daily by oral route for 14days. Group 3 – received aqueous aluminium chloride 500mg/kg followed by 2500mg/kg of liquid tiger nut extract daily by oral route for 14days and Group 4 – received aqueous aluminium chloride 500mg/kg followed by 3750mg/kg of liquid tiger nut extract daily by oral route for 14days. After sacrifice and tissue processing, groups 1 and 2 presented normal renal histology while groups 3 and 4 presented normal renal histology with lymphocytes between their distal convoluted tubules around the medulla. It was concluded that tiger nut has an ameliorative effect on AlCl3 induced histomorphological changes in the histology of kidney and it has no any negative effect on the histology of kidney.

查看原文本刊更多论文

虎坚果对氯化铝诱导的成年Wistar大鼠肾脏组织病理学的改善作用

虎坚果(Cyperus esculentus)在尼日利亚被称为豪萨语的aya，约鲁巴语的“Ofio”和伊博语的“Aki Hausa”，是一种可食用的多年生草状植物。虎坚果块茎可以吃零食，烤，油炸或烤和液体(Kunun aya)。虎坚果含有脂肪、蛋白质和碳水化合物(包括纤维和淀粉)。虎坚果可以用来“清除”和清除人体必需代谢反应和环境污染物产生的自由基。铝的主要排泄途径是肾脏。由于其反应性，铝在自然界中只与氯等其他元素结合，如氯化铝(AlCl3)。铝化合物用于各种食品、药品、生活用水、厨房设备。草药和化妆品。如果肾脏不能排出铝，它就会在体内积聚。本研究旨在探讨虎坚果对氯化铝诱导的wistar大鼠肾脏组织病变的保护作用。体重80 ~ 170g的成年雄性和雌性wistar大鼠20只，每组4只。组1 -对照组，给予生理盐水治疗14d，组2 -每日口服虎(乙醇提取物)坚果液1250mg，连用14d。第3组:氯化铝水溶液500mg/kg后，每日口服2500mg/kg虎坚果液体提取物，连续14天;第4组:氯化铝水溶液500mg/kg后，每日口服3750mg/kg虎坚果液体提取物，连续14天。经牺牲和组织处理后，1、2组肾组织正常，3、4组肾组织正常，髓质周围远曲小管间有淋巴细胞。由此可见，虎坚果对AlCl3诱导的肾脏组织形态学改变有改善作用，对肾脏组织形态学无负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bayero Journal of Pure and Applied Sciences

自引率

0.00%

发文量