ANTAGONISTIC EFFECTS OF CEFTRIAXONE AND SULPHADIMIDINE ON KETAMINE AND THIOPENTONE ANAESTHETICS IN NIGERIAN LOCAL DOG

Abstract

Antagonistic effects of ceftriaxone and sulphadimidine on ketamine and thiopentone anaesthetics were studied in Nigerian local dogs. Twenty – four Nigerian local dogs were used for the study. The dogs were divided into six groups: A, B, C, D, E, and F, with four dogs per group. Groups A and B were intravenously administered 17 mg/kg and 20 mg/kg body weight f thiopentone and ketamine respectively. But groups C and D were administered 23 mg/kg and 100mg/kg body weight of ceftriaxone and sulphadimidine respectively in addition to 20 mg/kg body weight of ketamine. However, groups E and F were administered intravenous dose of 23 mg/kg and 100 mg/kg of ceftriaxone and sulphadimidine respectively in addition to 17 mg/kg weight body of thiopentone. Vital parameters such as determination of anesthesia; onset and duration, temperature, respiratory and heart rates were recorded. The results of onset of duration of anesthesia revealed significant difference (P< 0.05) among group E, F and A animals. Although the result of onset anesthesia revealed significant difference between group A and B animals (P < 0.05). The values of respiratory rate revealed significant difference between the animals in groups D and B as well as groups F and A (P < 0.05). The values of heart rate showed significant difference between group C and D animals as well as between E and A animals (P < 0.05). Conclusively, sulphadimidine and cerftriaxone caused decreased duration of both anesthesia and onset of anesthesia when either was co-administered with ketamine or thiopentone in Nigerian local dogs. Sulphadimidine also caused increased respiratory rate, but cerftriaxone caused decreased and increased heart rate if co-administered with ketamine and thiopentone respectively. More so, thiopentone had higher durations of both anesthesia and onset of anesthesia in comparison with ketamine. So thiopentone is more potent than ketamine.