Antioxidant Activity of Cichorium intybus Extract in Concomitant Use with Melatonin Against Doxorubicin-induced Nephrotoxicity

IF 0.4 Q4 ONCOLOGY
Parisa Kiani Amin, Siamak Mashhady Rafie, S. Hesaraki, K. Amini
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引用次数: 0

Abstract

Background: Doxorubicin is preferred to cure many malignancies. Its nephrotoxicity is a dangerous nature that is to operate with a warning. Antioxidants accompanied by anticancer could moderate the various side effects. Objectives: Cichorium intybus (C. intybus) has nephron-protective effects. Melatonin stands as an antioxidant equivalent to others. The repairing effects of C. intybus-melatonin against the toxicity effects of doxorubicin on the kidneys were studied. Methods: Thirty 20 g to 25 g, balb/c mice were divided into 5 identical groups (n: 6). The research was grouped as control saline; DOX with the injection of doxorubicin; Chicory with the administration of the C. intybus complete extract following DOX; melatonin with the administration of the melatonin following DOX; both: with the administration of the chicory and melatonin following DOX. The histopathological study was set to determine degeneration, inflammation, and necrosis. Results: The mean of each histological phenomenon in the control group was significantly lower than in the DOX group. In the histopathology, we saw that all the treating groups, including C. intybus extract-received, melatonin-received, both of them received improved better than the doxorubicin-received group. The best improving mean was seen in the latter group. The DOX-induced nephrotoxicity could be improved by using the C. intybus extract and melatonin synchronously as therapeutic care. Conclusions: Synchronous administration of the chicory and melatonin has a healing potency against doxorubicin-induced nephrotoxicity.
菊石提取物与褪黑素联用抗阿霉素肾毒性的研究
背景:阿霉素是治疗许多恶性肿瘤的首选药物。它的肾毒性是一种危险的性质,需要警告操作。抗氧化剂与抗癌药物相结合,可以减轻各种副作用。目的:菊苣具有肾保护作用。褪黑素和其他抗氧化剂一样。研究了虫草褪黑素对阿霉素肾毒性的修复作用。方法:30只20 g ~ 25 g的balb/c小鼠随机分为5组(n: 6),实验组为对照生理盐水;DOX配合阿霉素注射液;菊苣经DOX处理后给予菊苣全提取物;褪黑素与在DOX后给予褪黑素;两者:在DOX后给予菊苣和褪黑素。组织病理学研究确定变性、炎症和坏死。结果:对照组各组织学现象的平均值均显著低于DOX组。在组织病理学上,我们看到所有的治疗组,包括接受虫草提取物、褪黑素的治疗组,他们的治疗效果都比接受阿霉素的治疗组好。后一组的平均改善效果最好。同时使用青虫草提取物和褪黑素作为治疗护理,可改善dox引起的肾毒性。结论:菊苣和褪黑素同步给药对阿霉素引起的肾毒性具有愈合效力。
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
67
期刊介绍: International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.
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