Local preventive effects of shakuyakukanzoto and paeoniflorin external gel on paclitaxel‐induced peripheral neuropathic pain in mice

Abstract

Chemotherapy for cancer patients induces peripheral neuropathic pain as a refractory side effect. We reported that the prophylactic repeated oral administration of a traditional herbal medicine, shakuyakukanzoto (SKT), peripherally inhibited paclitaxel‐induced mechanical allodynia in mice. In the present study, we therefore developed external gel forms of SKT and the major constituent paeoniflorin (PF), and evaluated their effects on paclitaxel‐induced mechanical allodynia in mice.