Enterosorbents from Abies Bark and their Therapeutic and Preventive Properties in Experimental Escherichiosis of Animals

Abstract

Methods have been developed for the preparation of enterosorbents by treating crushed abies bark with the 1.5% aqueous of NaOH solution or by extraction with hexane. It was found that all obtained enterosorbents have good sorption properties with respect to gelatin and methylene blue. The highest sorption activity for methylene blue was shown by a sample, obtained by extraction of abies bark with hexane (97.0 mg/g), and for gelatin sorption activity – a sample, obtained by treatment of abies bark with alkali (225.0 mg/g). It was found that the enterosorbent, obtained by treatment of abies bark with alkali solution both at a dose of 0.15 g per kg of animal weight (g/kg) and at a dose of 0.20 g/kg and the enterosorbent, obtained by extraction of abies bark with hexane at a dose of 0.20 g/kg, have the highest efficiency for the treatment and prevention of acute experimental Escherichiosis. From the considered methods of obtaining enterosorbents from abies bark for the treatment and prevention of gastrointestinal infections of animals, it is recomended to use a method based on treatment of abies bark with alkalai solution and apply the drug in a dose of 0.15 g/kg