Antimicrobial Activity of Albizzia Lebbeck Benth against Infectious Diarrhoea

B. Uma, K. Prabhakar, S. Rajendran, Y. L. Sarayu
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引用次数: 12

Abstract

Aim: Medicinal plants are an important therapeutic aid for various ailments. The invitro antimicrobial activity of Albizzia lebbeck. Benth was screened against some pathogens isolated from diarrhoeal patients.Procedure: The bark of the plant was powdered and extracted separately with aqueous, methanol, chloroform, petroleum ether and hexane using maceration technique. The antimicrobial activity was carried out by disc diffusion method and minimum inhibitory concentration by two-fold serial dilution method. The microorganisms tested include Enterotoxigenic E.coli, Enteropathogenic E.coli, Salmonella typhimurium, Salmonella enteritidis, Shigella dysenteria, Shigella flexineri, Candida albicans, Candida tropicalis and Candida krusei. Amikacin 10 μg/disc and fluconazole 10 μg/disc were used as standards.R esults: Aqueous, methanol and chloroform extracts exhibited activity against E.coli and Salmonella species. Petroleum ether and hexane extracts did not exhibit any activity. None of the extracts showed activity against Shigella and Candida species activity.C onclusion: This study revealed that the methanol extracts of Albizzia lebbeck was effective against E.coli and Salmonella strains associated with infectious diarrhoea. Further isolation of active compound responsible for the activity could be the potential sources of new antimicrobial agents
合欢花对感染性腹泻的抗菌活性研究
目的:药用植物是治疗各种疾病的重要辅助药物。合欢花体外抑菌活性研究。Benth对从腹泻患者中分离的一些病原体进行了筛选。操作步骤:将植物树皮制成粉末,分别用水、甲醇、氯仿、石油醚、己烷浸渍法提取。采用圆盘扩散法测定其抑菌活性,采用两倍连续稀释法测定最低抑菌浓度。检测的微生物包括产肠毒素大肠杆菌、肠致病性大肠杆菌、鼠伤寒沙门菌、肠炎沙门菌、痢疾志贺氏菌、屈曲志贺氏菌、白色念珠菌、热带念珠菌和克鲁氏念珠菌。以阿米卡星10 μg/盘、氟康唑10 μg/盘为标准。结果:水溶液、甲醇和氯仿提取物对大肠杆菌和沙门氏菌均有一定的抑制作用。石油醚和己烷提取物没有表现出任何活性。结论:本研究表明合欢甲醇提取物对感染性腹泻的大肠杆菌和沙门氏菌有较好的抑制作用。进一步分离出具有活性的活性化合物,可能成为新型抗菌药物的潜在来源
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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