Maternal Triglycerides level As Predictor of Fetal Macrosomia in Pregnant Women with Gestational Diabetes Mellitus

Abstract

Background: A diversity of characteristics have been identified in relation to increased risk of macrosomia, such as the high maternal age, height, pre-gestational body mass index (BMI), gravidity, overweight gain in gestation, post-term pregnancy, and male fetal sex. Objective: This study was carried out to find the relation between high level of maternal serum Triglycerides and fetal macrosomia in women with gestional diabetes. Materials and Methods: A prospective cohort study.one hunderd seventy pregnant women diagnosed with GDM singleton pregnancies attended to outpatient clinic for glucose control in Ain Shams Maternity Hospital were enrolled in the study; they were randomly divided into two groups: Group A: Diabetic pregnant female with hight levels of serum triglycerides. Group B: Diabetic pregnant female with normal lipid profile. Neonatal characteristics were collected from Both groups. Gestational age was calculated based on the combination of the last menstrual period and the early first-trimester ultrasound. Maternal metabolic parameters were included Serum glucose by oral glucose tolerance test and Blood Serum TG samples. Results: A highly statistically significant result in group A ( p-value < 0.001) indicates an increased incidence of fetal macrosomia with increased levels of serum TG. Conclusion: In women with gestational diabetes mellitus (GDM), higher levels of serum TG were associated with an increased incidence of fetal macrosomia.