Laurentius A. Lesmana , H.Ali Sulaiman , H.M. Sjaifoellah Noer , Fumio Tsuda , Hiroaki Okamoto
{"title":"Hepatitis C virus genotypes and co-infection with GB virus C in patients with anti-HCV-positive chronic liver disease in Jakarta, Indonesia","authors":"Laurentius A. Lesmana , H.Ali Sulaiman , H.M. Sjaifoellah Noer , Fumio Tsuda , Hiroaki Okamoto","doi":"10.1016/S0928-4346(96)00321-0","DOIUrl":null,"url":null,"abstract":"<div><p>Of 153 patients with chronic liver disease in Jakarta, Indonesia, who were positive for antibody to hepatitis C virus (HCV), 129 (84%) had HCV RNA in serum. HCV genotypes were II/1b in 55 (43%), III/2a in 33 (26%) and 1c in 15 (12%) patients; genotypes were not classifiable into the common five (I/1a, II/1b, III/2a, IV/2b and V/3a) or 1 c in the remaining 25 (19%) patients. RNA of a putative non-A-E hepatitis virus, designated GB virus C (GBV-C), was tested for by reverse-transcription polymerase chain reaction with nested primers deduced from the 5′-noncoding region, and detected in 18 (12%) patients of whom 14 (78%) possessed serum HCV RNA. These results indicate that 1c and the other indigenous genotypes of HCV, as well as the co-infection with GBV-C, would be common among Indonesian patients with HCV-associated chronic liver disease.</p></div>","PeriodicalId":13746,"journal":{"name":"International Hepatology Communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0928-4346(96)00321-0","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Hepatology Communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0928434696003210","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Of 153 patients with chronic liver disease in Jakarta, Indonesia, who were positive for antibody to hepatitis C virus (HCV), 129 (84%) had HCV RNA in serum. HCV genotypes were II/1b in 55 (43%), III/2a in 33 (26%) and 1c in 15 (12%) patients; genotypes were not classifiable into the common five (I/1a, II/1b, III/2a, IV/2b and V/3a) or 1 c in the remaining 25 (19%) patients. RNA of a putative non-A-E hepatitis virus, designated GB virus C (GBV-C), was tested for by reverse-transcription polymerase chain reaction with nested primers deduced from the 5′-noncoding region, and detected in 18 (12%) patients of whom 14 (78%) possessed serum HCV RNA. These results indicate that 1c and the other indigenous genotypes of HCV, as well as the co-infection with GBV-C, would be common among Indonesian patients with HCV-associated chronic liver disease.
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