Evaluation of hepatoprotective activity of leaf decoction of Ficus semicordata Buch.-Ham. ex Sm. in Charles Foster albino rats

Journal of Indian System of Medicine Pub Date : 2021-10-01 DOI:10.4103/jism.jism_53_21

Shashi Gupta, R. Acharya, M. Nariya

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Abstract

Background: Bhuidumri, distinctive of the folklore floras of Odisha, is recognized as Ficus semicordata Buch.-Ham. ex Sm., family Moraceae. The leaves of Bhuidumri are recounted for their traditional usage and they are used to treat jaundice, stomach ailments, wound, indigestion, liver ailment, and skin diseases. The present research article aims at exploring the hepatoprotective activity of leaf decoction of F. semicordata in Charles Foster albino rats. Materials and Methods: The dried leaves of F. semicordata were prepared into powder, and the decoction (kwatha) form was used in accordance with the Ayurvedic Pharmacopeia of India. The hepatoprotective activity of a trial drug (4.5 mL/kg, po) was assessed against thioacetamide-persuaded hepatotoxicity in Charles Foster albino rats. Silymarin (100 mg/kg, po) was used as a reference standard drug in a positive control group. Results: Thioacetamide-treated rats revealed a nonsignificant increase in SGPT (665.00 ± 298.96) and SGOT (1196.67 ± 540.38) in comparison with the normal control group. The F. semicordata kwatha-treated group revealed a nonsignificant increase in SGPT (1091.80 ± 558.23) and SGOT (2652.00 ± 944.83) in comparison with the thioacetamide control group. Sylimarin revealed a nonsignificant decrease in SGPT (110.80 ± 20.62) and SGOT (425.60 ± 157.74) in comparison with the thioacetamide control group. Microscopic examination of liver sections from normal control rats exhibited normal cytoarchitecture; thioacetamide-administered rats and F. semicordata kwatha-treated group with thioacetamide showed severe centrilobular necrosis and polymorphonuclear leukocytes (PMN) infiltration, multifocal Grade [3]. The reference standard group-treated groups showed mild necrosis and PMN infiltration with fatty changes, Grade [1]. Conclusion: F. semicordata leaf kwatha is nonhepatoprotective on thioacetamide-induced liver toxicity in rats at the given dose and dosage form.

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半榕叶煎液的保肝活性评价。Sm。在查尔斯·福斯特白化大鼠中

背景:Bhuidumri是奥里萨邦独特的民俗植物群，被认为是Ficus semi - data buchh . ham。Sm。，桑科。Bhuidumri叶子的传统用途是用来治疗黄疸、胃病、伤口、消化不良、肝脏疾病和皮肤病。本研究旨在探讨半荆芥叶煎剂对白化病大鼠的保肝作用。材料与方法:将半荆芥干燥后的叶子制成粉末，按照印度阿育吠陀药典采用水煎(瓜塔)形式。研究了一种试验性药物(4.5 mL/kg, po)对Charles Foster白化病大鼠硫代乙酰胺诱导肝毒性的保护作用。阳性对照组以水飞蓟素(100 mg/kg, po)作为对照标准药物。结果:与正常对照组相比，硫乙酰胺处理大鼠的SGPT(665.00±298.96)和SGOT(1196.67±540.38)无显著升高。治疗组SGPT(1091.80±558.23)和SGOT(2652.00±944.83)较硫乙酰胺对照组无显著升高。与硫乙酰胺对照组相比，Sylimarin组SGPT(110.80±20.62)和SGOT(425.60±157.74)无显著降低。正常对照大鼠肝脏切片镜检显示细胞结构正常;硫代乙酰胺给药组大鼠和硫代乙酰胺治疗组大鼠出现严重小叶中心坏死和多形核白细胞(PMN)浸润，多灶[3]级。参考标准组治疗组表现为轻度坏死，PMN浸润伴脂肪改变，[1]级。结论:在一定剂量和剂型下，半荆芥叶番瓜对硫代乙酰胺所致大鼠肝毒性无肝保护作用。

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Journal of Indian System of Medicine

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