Association between the concentrations of some toxic metals and the risk of uterine fibroids among Nigerian women

Mathias Abiodun Emokpae, FatimohBukola Kareem
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Abstract

Background: Uterine fibroids are a major health challenge to some women in the world, especially women of African descendants. The etiology of uterine fibroids and the mechanisms of their growth are not fully understood, and those factors that make women to be susceptible to fibroid development are subjects of investigation. Environmental toxicants such as toxic metals exposure have been implicated, but the results have not been consistent. This study seeks to determine the association between blood cadmium (Cd), arsenic (As), and lead (Pb) levels and the risk of uterine fibroids among women of reproductive age. Materials and Methods: This case–control study comprised 100 women of reproductive age (age range, 20–50 years) with uterine fibroid and 50 age-matched women without uterine fibroids. Fibroids were diagnosed using abdominal scan by attending physicians. Furthermore, the control subjects were screened for fibroids using abnormal scan. Blood Cd, As, and Pb were determined using an atomic absorption spectrophotometer, and the risk of association was calculated. Results: The mean blood Cd, As, and Pb were significantly higher (P < 0.001) among women with fibroid than those without fibroid (controls). The odds ratio for Cd 2.62 (confidence interval [CI]: 0.02–0.05), As 1.02 (CI: 0.02–0.030), and Pb 1.42 (CI: 0.04–0.129) was greater among women with uterine fibroids than controls. Conclusions: Exposure to cadmium and lead might be a risk factor for developing uterine fibroids among Nigerian women.
尼日利亚妇女中某些有毒金属浓度与子宫肌瘤风险之间的关系
背景:子宫肌瘤是世界上一些妇女的主要健康挑战,特别是非洲裔妇女。子宫肌瘤的病因及其生长机制尚不完全清楚,那些使妇女易患子宫肌瘤的因素是研究的对象。环境有毒物质,如有毒金属暴露也有牵连,但结果并不一致。本研究旨在确定育龄妇女血液中镉(Cd)、砷(As)和铅(Pb)水平与子宫肌瘤风险之间的关系。材料与方法:本病例对照研究纳入100名育龄妇女(年龄范围:20-50岁)子宫肌瘤和50名年龄匹配的无子宫肌瘤妇女。肌瘤由主治医生通过腹部扫描诊断。此外,对照组使用异常扫描筛查肌瘤。采用原子吸收分光光度计测定血Cd、As、Pb,并计算关联风险。结果:有肌瘤的妇女血Cd、As、Pb的平均值明显高于无肌瘤的妇女(对照组)(P < 0.001)。子宫肌瘤患者的比值比Cd为2.62(可信区间[CI]: 0.02-0.05)、As为1.02(可信区间[CI]: 0.02-0.030)、Pb为1.42(可信区间:0.04-0.129)均高于对照组。结论:接触镉和铅可能是尼日利亚妇女发生子宫肌瘤的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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