Hepatoprotective activity of Limnophila repens against paracetamol-induced hepatotoxicity in rats

Abstract

Aim: The present work was performed to assess the hepatoprotective activity of Limnophila repens against paracetamol toxicity in Wistar rats. Materials and Methods: Hepatoprotective properties of the methanol extract of the whole plant had been examined on paracetamol-induced hepatotoxicity. Hepatotoxicity was evoked in albino Wistar rats by the administration of paracetamol (2 g/kg), p.o. for 7 days. The methanol extract of L. repens was administered at the doses 100–200 mg/kg/day, p.o. for 7 days. Serum analysis was performed to estimate the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, total bilirubin, cholesterol, and proteins. Histopathology studies were worked on the catalase liver samples. Results: The noxious effects of paracetamol had been considerably controlled in the extract treated groups that were demonstrated by the restoration of serum biochemical parameters to near normal levels. Conclusions: From the research, it had been figured that L. repens have significant hepatoprotective properties.