Cardio protective activity of Sargassum wightii on isoproterenol induced myocardial stress in rats

IF 0.5 4区地球科学 Q4 Earth and Planetary Sciences

Indian Journal of Geo-Marine Sciences Pub Date : 2022-05-01 DOI:10.56042/ijms.v51i05.65572

R. E. Renitta, S. Rosariob, P. J. J. Cypriyanac, A. V. Samrotd, S. Dhivae, S. Abiramif, P. Prakashc

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引用次数: 0

Abstract

The aim of this investigation is to determine whether the methanolic extracts of Sargassum wightii can protect rats against isoproterenol-induced myocardial infarction. Four different groups of rats (6 rats in each group) were taken; where group 1 comprised of normal untreated rats, group 2 was injected with Isoproterenol (synthetic catecholamine), group 3 was considered as standard and hence, was injected with Isoproterenol + Simvastatin and group 4 was treated with Isoproterenol + Sargassum wightii ’s extract. Cardioprotective effects of Sargassum wightii was observed via the changes in the lipid profile, cardio marker enzymes and through histopathological studies. Rats treated with the extract of S . wightii showed a significant reduction in total cholesterol, LDL-cholesterol, serum triglycerides and increase in HDL- cholesterol level indicating an undamaged myocardial membrane. Likewise, low enzyme activity in Sargassum wightii treated rats clearly indicated the cardioprotective effects of Sargassum wightii. Histopathological studies were also done to observe the changes on the rats at the tissue level and no pathological changes were observed in Sargassum wightii treated rats. Hence, methanolic extract of Sargassum wightii is evidenced to possess cardioprotective activity against myocardial infarction.

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马尾草对异丙肾上腺素诱导大鼠心肌应激的心脏保护作用

探讨马尾草甲醇提取物对异丙肾上腺素致大鼠心肌梗死的保护作用。取4组大鼠，每组6只;其中，1组为正常未用药大鼠，2组注射异丙肾上腺素(合成儿茶酚胺)，3组作为标准注射异丙肾上腺素+辛伐他汀，4组注射异丙肾上腺素+马尾藻提取物。通过脂质谱、心肌标记酶和组织病理学研究，观察了马尾藻对心脏的保护作用。大鼠经枸杞提取物治疗。wightii显示总胆固醇、低密度脂蛋白胆固醇、血清甘油三酯显著降低，高密度脂蛋白胆固醇水平升高，表明心肌膜未受损。同样，马尾藻处理大鼠体内的低酶活性清楚地表明了马尾藻对心脏的保护作用。组织病理学观察大鼠在组织水平上的变化，马尾藻处理大鼠未见病理改变。因此，马尾草甲醇提取物对心肌梗死具有保护心脏的作用。

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来源期刊

Indian Journal of Geo-Marine Sciences 地学-海洋学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

1.7 months

期刊介绍： Started in 1972, this multi-disciplinary journal publishes full papers and short communications. The Indian Journal of Geo-Marine Sciences, issued monthly, is devoted to the publication of communications relating to various facets of research in (i) Marine sciences including marine engineering and marine pollution; (ii) Climate change & (iii) Geosciences i.e. geology, geography and geophysics. IJMS is a multidisciplinary journal in marine sciences and geosciences. Therefore, research and review papers and book reviews of general significance to marine sciences and geosciences which are written clearly and well organized will be given preference.