Relationship between Common Dietary Polyphenols and Obesity-Induced Inflammation

Lada Tucakovic, N. Colson, I. Singh
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引用次数: 10

Abstract

The incidence of obesity and its related metabolic disorders has escalated dramatically in the past decades worldwide. Defined as abnormal or excessive fat accumulation caused by an imbalance between energy intake and expenditure, obesity is presently the major health challenge in developed countries and the causative factor of numerous diseases such as heart problems, hypertension, hyperlipidemia and type 2 diabetes. Presence of high level of cytokines and acute phase proteins associated with inflammation in obese individuals relates obesity to chronic low-grade inflammation. Obesity-induced inflammation has an impact on insulin resistance and cardiac health. Polyphenols including catechins, tocopherols, resveratrol, curcumin and anthocyanins have been shown to reduce adipose tissue inflammation. It has been broadly accepted that adipocyte dysfunction plays a major role in development of obesity and obesity related complications. This state is characterised by hypersecretion of pro-atherogenic, pro-inflammatory and pro-diabetic adipokines as well as decreased secretion of adiponectin. The dietary polyphenols described in this review have potential as nutritional strategies for the prevention of obesity and associated inflammation as well as increase in insulin sensitivity in diabetic people.
常见膳食多酚与肥胖诱导炎症的关系
在过去的几十年里,世界范围内肥胖及其相关代谢紊乱的发病率急剧上升。肥胖被定义为由于能量摄入和消耗之间的不平衡而导致的异常或过度的脂肪积累,是目前发达国家面临的主要健康挑战,也是心脏病、高血压、高脂血症和2型糖尿病等许多疾病的致病因素。肥胖个体中与炎症相关的高水平细胞因子和急性期蛋白的存在将肥胖与慢性低度炎症联系起来。肥胖引起的炎症对胰岛素抵抗和心脏健康有影响。包括儿茶素、生育酚、白藜芦醇、姜黄素和花青素在内的多酚已被证明可以减少脂肪组织的炎症。脂肪细胞功能障碍在肥胖及肥胖相关并发症的发生中起着重要作用,这一观点已被广泛接受。这种状态的特征是促动脉粥样硬化、促炎症和促糖尿病的脂肪因子的高分泌,以及脂联素的分泌减少。本综述中描述的膳食多酚有可能作为预防糖尿病患者肥胖和相关炎症以及胰岛素敏感性增加的营养策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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