Evaluation of the Protective Effects of Savliv Drops in CCL4- Induced Hepatic Fibrosis Albino Rats -

Abstract

Savliv® suspension, is an herbal drug for liver cirrhosis treatment developed by Indian scientists, used to prevent the liver fibrosis induced by carbon tetrachloride (CCL4) in male albino rats. This study provides further evidence on its role as a hepato-therapeutic agent in the experimental rats with CCL4 -induced liver fibrosis. Then Liver tissue and serum were collected. Oral administration of savliv®) drops (750 and 500µl /rat) after CCL4-fibrosis induction showed a significant decrease in the collagen fibre formation and cell membrane destruction. Histopathological examination revealed the regression of collagen fiber and connective tissues percentage between the liver lobules in the CCL4- induced liver fibrotic rats (G4&5) and reconstruction - regeneration of the damaged liver cells after treated rats (G4&5) with savliv drops (750 and 500µl /rat) at week 8, in a dose dependent manner. The serum levels of Glutamic-Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT), and alkaline phosphatse (ALP) enzymes were significantly increased in the CCL4-model group in comparison with the control groups (oil: vehicle). Treatment with savliv® drops showed a marked reduction in the above condition. These results further support that the Savliv® drops has the potency of curative effects for liver fibrotic cells induced by toxic agent.