Relationship between post-op central corneal thickness and steroid-induced ocular hypertension following myopic photorefractive keratectomy

Advances in ophthalmology & visual system Pub Date : 2020-11-23 DOI:10.15406/AOVS.2020.10.00398

Hina Manzoor, A. Batool, S. Akram, Iqra Khalil, Ammara Affi

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引用次数: 1

Abstract

Purpose: Purpose of this study is to determine the relationship between Post-op central corneal thickness and steroid-induced ocular hypertension following myopic photorefractive keratectomy. Methods: This longitudinal analytical study was carried on 50 patients, both gender and age ranging from 20-40 years who had undergone myopic PRK refractive surgery. The data collected from The Department of Ophthalmology in Madina Teaching Hospital Faisalabad in the duration of 11 months from July 2019 to May 2020. IOP measured by Goldmann applanation tonometer. Recorded IOP greater than 21mmHg was considered as Ocular hypertension (OHT). The post-Op follow-up was conducted 1 day, 1 week, 2-3 weeks, and 4-6 weeks. The CCT and IOP was evaluated carefully. Data was noted on Performa. Data was analyzed by using Descriptive and Repeated Measures ANOVA by using the latest version 21 of SPSS. Results: Out of 50 patients’ 46% were males and 54% were females. The mean score of CCT pre & post operatively for right eye and left eye was 529.28±34.74 & 462.56±40.20 and 529.18±37.2, 462.44±42.60 respectively. Statistically significant effect was seen on post-op central corneal thickness and steroid induced ocular hypertension, according to the results of repeated measure ANOVA. Thinner corneas were more susceptible to steroids induced OHT. In various post-op central corneal thickness, it was observed that patients with thinner corneal thickness ranges 413±4.24 to 449.33±48.29 in right eye and 455.8±56.42 to 456.83±50.52 are more affected by topical steroids used. Males were more affected than females due to decreased central corneal thickness. Elderly patients were more susceptible to steroid-induced ocular hypertension post-operatively. Conclusion: Post-op steroid induced ocular hypertension is affecting by central corneal thickness. Male and elderly individual are more susceptible to steroid-induced ocular hypertension following myopic PRK. Post-Op use of topical steroids cause ocular hypertension in thinner corneas

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近视屈光性角膜切除术后角膜中央厚度与激素性高眼压的关系

目的:本研究的目的是确定近视屈光性角膜切除术后角膜中央厚度与激素性高眼压的关系。方法:对50例20 ~ 40岁的近视PRK屈光手术患者进行纵向分析研究。数据收集自费萨拉巴德麦地那教学医院眼科，时间为2019年7月至2020年5月，共11个月。用Goldmann眼压计测量眼压。IOP大于21mmHg被认为是高眼压(OHT)。术后随访1天、1周、2-3周、4-6周。仔细评估CCT和IOP。数据记录在performance上。数据分析采用描述性和重复测量方差分析，采用最新版本的SPSS 21。结果:50例患者中男性46%，女性54%。右眼、左眼CCT术前、术后平均评分分别为529.28±34.74、462.56±40.20、529.18±37.2、462.44±42.60。根据重复测量方差分析结果，术后角膜中央厚度和类固醇引起的高眼压有统计学意义。较薄的角膜更容易受到类固醇诱导的OHT的影响。在不同的术后角膜中央厚度中，观察到右眼角膜厚度较薄的患者(413±4.24 ~ 449.33±48.29)和局部使用类固醇激素的患者(455.8±56.42 ~ 456.83±50.52)受影响较大。由于角膜中央厚度减少，男性比女性更容易受到影响。老年患者术后更容易发生激素性高眼压。结论:术后类固醇性高眼压受角膜中央厚度的影响。男性和老年人在近视PRK后更容易发生类固醇性高眼压。术后使用局部类固醇引起薄角膜的高眼压

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Advances in ophthalmology & visual system

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