In Silico Identification of Interaction between Ageing and Cardiovascular Disease Genes

Abstract

Heart is the central organ that pumps pure blood to whole body through blood vessels. This circulation system involves functioning of large number of genes that interacts for proper functioning. Any malfunctioning of single gene leads to the cardiovascular diseases (CVDs) Aging is an inevitable part of life and unfortunately the risk of CVDs increases with ageing. Although numerous studies were carried on cardiovascular diseases that considered both young and aged humans, but still there are many unanswered questions as to how the genetic pathways that regulate aging influence cardiovascular disease and vice versa. Therefore, this is of great interest to identify the interaction between cardiovascular diseases and ageing genes. Genes for CVDs and ageing were collected from various databases and a network was created for their common genes. Network in analyzed to find the interaction between ageing and cardiovascular disease genes.