Association between Serum C-peptide Level and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients on Oral Anti-diabetic Drug

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Bangladesh Journal of Medical Science Pub Date : 2023-09-07 DOI:10.3329/bjms.v22i4.67106

Adhir Kumar Das, R. Tasnim, Jahidul Islam

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Abstract

Background: Diabetic Nephropathy (DN) treatment focuses mostly on preventing or delaying disease development. The most recent research indicates that C-peptide may have a favourable biological effect on DN. In type 2 Diabetes Mellitus, the link between C-peptide level and DN is poorly understood (DM). The purpose of this study is to evaluate the relation between serum C-peptide and diabetic nephropathy in type 2 DM patients taking an oral anti diabetic medication. Methods: From July 2019 to June 2020, a cross-sectional observational study was done at the Department of Pharmacology and Therapeutics at Dhaka Medical College, Dhaka. A total of 63 randomly selected type 2 diabetes patients met the inclusion criteria. SPSS was used to collect, record, and evaluate biochemical values including FBG, 2hrs ABF, HbA1c, urine for microalbumin, serum creatinine, and serum C-peptide. Result: Among 63 study participants, 40 (63.5%) were female and 23 (36.5%) were male. Mean age of patients was 50.30±10.55 years. Mean duration of DM of total study subjects was 6.29±3.15 years. Out of total study subjects, 17.5% (11) had low serum C-peptide, 74.6% (47) had normal serum C-peptide and 7.9% (5) had high serum C-peptide level. Correlations of clinical and biochemical variables showed negative correlation between serum C-peptide level and microalbumin, DM duration, FBS, 2hrs ABF, HbA1c, creatinine. Mean urine albumin was higher in patients with low serum C-peptide level. The microalbumin level and the duration of DM of study subjects are significantly associated with serum C-peptide. Conclusion: In this study we have found that type 2 diabetic individuals with low serum C-peptide levels have a high frequency of diabetic nephropathy and that serum C-peptide levels are significantly associated with diabetic nephropathy. Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 768-772

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口服降糖药2型糖尿病患者血清c肽水平与糖尿病肾病的关系

背景:糖尿病肾病(DN)的治疗主要集中在预防或延缓疾病的发展。最近的研究表明，c肽可能对DN有良好的生物学作用。在2型糖尿病中，c肽水平与DN之间的关系尚不清楚(DM)。本研究旨在探讨口服抗糖尿病药物的2型糖尿病患者血清c肽与糖尿病肾病的关系。方法:2019年7月至2020年6月，在达卡医学院药理学和治疗学系进行了一项横断面观察研究。随机选择63例符合纳入标准的2型糖尿病患者。使用SPSS软件收集、记录和评价生化指标，包括空腹血糖、2hrs ABF、糖化血红蛋白、尿微量白蛋白、血清肌酐和血清c肽。结果:63名研究对象中，女性40人(63.5%)，男性23人(36.5%)。患者平均年龄50.30±10.55岁。研究对象DM的平均病程为6.29±3.15年。在所有研究对象中，17.5%(11人)血清c肽水平低，74.6%(47人)血清c肽水平正常，7.9%(5人)血清c肽水平高。血清c肽水平与微量白蛋白、糖尿病病程、FBS、2hrs ABF、HbA1c、肌酐呈负相关。血清c肽水平低的患者平均尿白蛋白较高。研究对象的微量白蛋白水平和糖尿病持续时间与血清c肽显著相关。结论:本研究发现血清c肽水平低的2型糖尿病患者糖尿病肾病发生率高，且血清c肽水平与糖尿病肾病有显著相关性。孟加拉国医学杂志，第22卷第4期，23年10月，第768-772页

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