Simulation of Cadmium and Lead Uptake into Saliva from Children's Pacifiers using the Joint Expert Speciation System

Boniphace E. Majinyali, Paul W. Jones
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Abstract

Abstract The ingestion of certain trace metals has been a major concern of the world and there have been links to cancer, renal failure, anemia, cardiovascular and reproductive complications. Pacifiers are amongst the childcare objects that may expose children to potentially toxic metals through mouthing behaviors. Despite high levels of hazardous chemicals reported in some childcare products including pacifiers, there has been limited information on the chemical species formed in saliva and as a result their bioavailability levels. Using the Joint Expert Speciation System, this study determined chemical speciation and predicted bioavailability at a range of 18–92% for cadmium and 1–23% for lead of the total metal concentrations through the creation of simulated saliva models at low and high pH. The degree of predicted uptake using a net-neutral species approach was dependent on the total concentrations of lead and cadmium within a standard range of low molecular mass ligands and the pH of the saliva. These saliva models predicted cadmium to be more bioavailable than lead, indicating there may be an elevated risk from the mouthing action of pacifiers or similar items containing cadmium compared to lead. This study, therefore, offers regulatory bodies opportunities to strengthen safety compliance monitoring for materials used in pacifiers.
使用联合专家物种分类系统模拟儿童奶嘴对唾液中镉和铅的吸收
某些微量金属的摄入一直是世界关注的主要问题,并且与癌症、肾衰竭、贫血、心血管和生殖并发症有关。安抚奶嘴是可能通过嘴部行为使儿童接触到潜在有毒金属的儿童用品之一。尽管据报道,包括奶嘴在内的一些儿童保育产品中含有高浓度的有害化学物质,但关于唾液中形成的化学物质种类及其生物利用度的信息有限。使用联合专家物种形成系统,本研究确定化学物种形成和预测生物利用度的范围18 - 92%,铅镉和1 - 23%的总金属浓度的唾液通过创建模拟模型在低和高博士的程度预测吸收使用净中性物种的方法是依赖于总铅和镉的浓度在标准范围内的低分子质量配体和唾液的pH值。这些唾液模型预测镉比铅更具生物可利用性,这表明与含铅相比,含镉的奶嘴或类似物品的口腔动作可能会增加风险。因此,这项研究为监管机构提供了加强对安抚奶嘴所用材料的安全合规监测的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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