Evaluating STC-1 and STC-2 mRNA expressions in Schizophrenia patients with increased oxidative stress

IF 0.5 4区医学 Q4 PSYCHIATRY

Annales medico-psychologiques Pub Date : 2024-11-01 DOI:10.1016/j.amp.2023.02.005

Sevgi Karabulut Uzunçakmak , Halil Özcan , Ebubekir Dirican , Ayşegül Tavacı Özçelik

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引用次数: 0

Abstract

Introduction

Schizophrenia is a chronic psychiatric disorder characterized by cognitive impairment. Oxidative stress is associated with disease progression in patients with schizophrenia. Stanniocalcin (STC)-1 and STC-2 are two proteins commonly expressed in mammals belonging to the stanniocalcin family and they are involved in oxidative stress. The aim of this study is to investigate STC-1 and STC-2 mRNA expressions in schizophrenia patients with altered oxidative stress parameters.

Methods

For this purpose, 70 patients with schizophrenia and 40 healthy individuals were recruited for the study. Peripheral blood samples were obtained from all participants. Glutathione (GSH) activities, superoxide dismutase (SOD) activities, and malondialdehyde (MDA) levels were measured. STC-1 and STC-2 expressions were assessed by real-time polymerase chain reactions.

Results

SOD activity levels were lower in patients than in healthy individuals (p = 0.0309), while the patients’ MDA levels were higher (p = 0.039). STC-1 and STC-2 expressions were lower in patients than in healthy individuals (p = 0.1049 and p < 0.0001, respectively). Furthermore, these two genes had a positive correlation among the patients (r = 0.435, p = 0.0025). According to area under the curve (AUC) values, STC-2 (AUC = 0.8332, p < 0.0001) had better diagnostic power than STC-1 (AUC = 0.6167, p = 0.1037).

Conclusions

The expression of stanniocalcins in schizophrenia was investigated here for the first time. Decreased STC-2 expression in patients with schizophrenia with increased oxidative stress parameters may guide the understanding of the pathophysiological mechanisms caused by oxidative stress, which may be increased in cognitive diseases such as schizophrenia, and it also has the potential to be a prognostic factor that can be used in the diagnosis of schizophrenia.

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评估氧化应激增加的精神分裂症患者中 STC-1 和 STC-2 mRNA 的表达情况

导言精神分裂症是一种以认知障碍为特征的慢性精神疾病。氧化应激与精神分裂症患者的病情发展有关。司坦尼钙蛋白（STC）-1和STC-2是哺乳动物中常见的两种蛋白，属于司坦尼钙蛋白家族，它们参与氧化应激。本研究旨在调查氧化应激参数改变的精神分裂症患者中 STC-1 和 STC-2 mRNA 的表达情况。研究人员采集了所有参与者的外周血样本。测量谷胱甘肽（GSH）活性、超氧化物歧化酶（SOD）活性和丙二醛（MDA）水平。结果患者的 SOD 活性水平低于健康人（P = 0.0309），而患者的 MDA 水平较高（P = 0.039）。患者的 STC-1 和 STC-2 表达量低于健康人（分别为 p = 0.1049 和 p < 0.0001）。此外，这两个基因在患者中呈正相关（r = 0.435，p = 0.0025）。根据曲线下面积（AUC）值，STC-2（AUC = 0.8332，p = 0.0001）比 STC-1（AUC = 0.6167，p = 0.1037）具有更好的诊断能力。在氧化应激参数升高的精神分裂症患者中，STC-2的表达减少可能会引导人们了解氧化应激引起的病理生理机制，而氧化应激在精神分裂症等认知疾病中可能会增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annales medico-psychologiques 医学-精神病学

CiteScore

1.30

自引率

33.30%

发文量

196

审稿时长

4-8 weeks

期刊介绍： The Annales Médico-Psychologiques is a peer-reviewed medical journal covering the field of psychiatry. Articles are published in French or in English. The journal was established in 1843 and is published by Elsevier on behalf of the Société Médico-Psychologique. The journal publishes 10 times a year original articles covering biological, genetic, psychological, forensic and cultural issues relevant to the diagnosis and treatment of mental illness, as well as peer reviewed articles that have been presented and discussed during meetings of the Société Médico-Psychologique.To report on the major currents of thought of contemporary psychiatry, and to publish clinical and biological research of international standard, these are the aims of the Annales Médico-Psychologiques.