Co-expression of Matrix Metalloproteinase 9 (MMP9) and Motility-related Protein-1 (MRP-1/CD9) in Human Breast Cancer

IF 0.4 Q4 ONCOLOGY

International Journal of Cancer Management Pub Date : 2022-11-15 DOI:10.5812/ijcm-105009

Shabnam Khalilnezhad, R. Safaralizadeh, Mohammad Ali Hosseini PourFeizi, Ahad Khalilnezhad, D. Amani

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引用次数: 0

Abstract

Background: Controversial evidence exists regarding the metastasis-suppressor or promoting activity of motility-related protein-1 (MRP-1/CD9) in breast cancer (BC). Objectives: we aimed at investigating the possible correlation of CD9 with a metastasis marker matrix metalloproteinase 9 (MMP9) in human BC tissues. Methods: A total of 19 BC and 5 normal breast tissues were analyzed. The mRNA expression of CD9 and MMP9 was measured by quantitative PCR. The correlation of genes’ expression with each other and clinicopathological features (i. e. tumor pathology, grade, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), P53, and KI67) was tested by relevant statistical analysis methods. Results: There was no significant difference between patients with BC and the control group regarding the expression of MMP9 (P = 0.394) and CD9 (P = 0.887). A significant strong positive correlation was observed between CD9 and MMP-9 expressions (r = 0.761 and P = 0.0002). The MMP9 expression was significantly higher in ER or PR positive compared to ER or PR negative tumors (P = 0.046). Conclusions: Given the strong correlation with MMP9, it seems that CD9 might have a role in metastasis in human BC. However, much more studies are required to further support this hypothesis.

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基质金属蛋白酶9 (MMP9)和动力相关蛋白1 (MRP-1/CD9)在人乳腺癌中的共表达

背景:关于乳腺癌(BC)中运动相关蛋白-1 (MRP-1/CD9)的转移抑制或促进活性存在争议的证据。目的:研究人BC组织中CD9与转移标志物基质金属蛋白酶9 (MMP9)的相关性。方法:对19例BC和5例正常乳腺组织进行分析。定量PCR检测CD9、MMP9 mRNA表达。采用相关统计分析方法检验基因表达与临床病理特征(肿瘤病理、分级、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2 (HER-2)、P53、KI67)的相关性。结果:BC患者与对照组MMP9 (P = 0.394)、CD9 (P = 0.887)表达差异无统计学意义。CD9与MMP-9表达呈显著正相关(r = 0.761, P = 0.0002)。MMP9在ER或PR阳性肿瘤中的表达明显高于ER或PR阴性肿瘤(P = 0.046)。结论:考虑到CD9与MMP9的强相关性，CD9可能在人BC的转移中起作用。然而，需要更多的研究来进一步支持这一假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Cancer Management ONCOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.