Biohumoral and comorbidity determinants of low HDL-C during acute phase response in a setting of in-hospital patients

Q Medicine

Clinical Lipidology Pub Date : 2015-06-01 DOI:10.2217/clp.15.17

S. Vuono, M. Ricci, A. Villa, A. Gentili, M. Scavizzi, G. Ciuffetti, M. Pirro, C. Ferri, G. Lupattelli

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引用次数: 1

Abstract

Abstract Aim: To evaluate, in a large population, differences in HDL levels between subjects with acute phase reaction (APR) and subjects without different HDL decreases depending on disease causing APR and correlations between HDL and APR parameters. Materials & methods: In 902 patients we retrospectively evaluated alpha-2-globulins, white blood cells, C-reactive protein (CRP) and lipid profiles. APR was defined by CRP >1.5 mg/dl. Patients were reselected in seven subsets: infections, rheumatic diseases, neoplasms, cerebro-cardiovascular diseases, traumatic/mental disorders, endocrine/metabolic diseases and controls. Results: Subjects with APR showed significantly lower HDL-C (age and gender adjusted). Subset ‘infections’ showed the lowest HDL-C values and the highest CRP values. HDL-C had inverse significant correlation with all APR parameters. At stepwise regression analysis gender, albumin, TG and CRP were independent predictors of HDL-C. Conclusion: Our data produced the observation that subjects with APR show HDL-C levels lower than non-APR subjects to a large and heterogeneous population. HDL-C levels decrease in a different manner on the basis of the disease causing APR, maybe depending on inflammation intensity.

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住院患者急性期低HDL-C的生物体液和合并症决定因素

摘要目的:评价在大人群中，急性期反应(APR)患者与非急性期反应(APR)患者HDL水平的差异，其差异取决于APR的病因以及HDL与APR参数之间的相关性。材料与方法:在902例患者中，我们回顾性地评估了α -2-球蛋白、白细胞、c反应蛋白(CRP)和脂质谱。以CRP >1.5 mg/dl定义APR。在七个亚组中重新选择患者:感染、风湿病、肿瘤、脑血管疾病、创伤/精神障碍、内分泌/代谢疾病和对照。结果:APR患者的HDL-C(年龄和性别调整后)明显降低。亚组“感染”显示最低的HDL-C值和最高的CRP值。HDL-C与APR各参数呈显著负相关。在逐步回归分析中，性别、白蛋白、TG和CRP是HDL-C的独立预测因子。结论:我们的数据显示，在大量异质人群中，APR患者的HDL-C水平低于非APR患者。在引起APR的疾病的基础上，HDL-C水平以不同的方式下降，可能取决于炎症强度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Lipidology 生物-生化与分子生物学

CiteScore

0.44

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Clinical Lipidology is published to support the diverse array of medical professionals who work to reduce the incidence of morbidity and mortality from dyslipidemia and associated disorders of lipid metabolism. The Journal''s readership encompasses a broad cross-section of the medical community, including cardiologists, endocrinologists, and primary care physicians, as well as those involved in the treatment of such disorders as diabetes, hypertension, and obesity. The Journal also addresses allied health professionals who treat the patient base described above, such as pharmacists, nurse practitioners and dietitians. Because the scope of clinical lipidology is broad, the topics addressed by the Journal are equally diverse. Typical articles explore lipidology as it is practiced in the treatment setting, recent developments in pharmacological research, reports of treatment and trials, case studies, the impact of lifestyle modification, and similar academic material of interest to the practitioner. While preference is given to material of immediate practical concern, the science that underpins lipidology is forwarded by expert contributors so that evidence-based approaches to reducing cardiovascular and coronary heart disease can be made immediately available to our readers. Sections of the Journal will address pioneering studies and the clinicians who conduct them, case studies, ethical standards and conduct, professional guidance such as ATP and NCEP, editorial commentary, letters from readers, National Lipid Association (NLA) news and upcoming event information, as well as abstracts from the NLA annual scientific sessions and the scientific forums held by its chapters, when appropriate.