Protective effects of aldioxa tablets on aspirin-induced gastric mucosal lesions in rats

胃肠病学和肝病学杂志 Pub Date : 2011-06-20 DOI:10.3760/CMA.J.ISSN.1008-1372.2011.06.014

Yi Fu, Xin-yan Zhang, M. Cui, Xian-min Liu, Fangxiang Mou

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Abstract

Objective To study the protective effects of aldioxa tablets on ethanol-induced gastric mucosal lesions in rats,and explore the potential pathogenesis.Methods Sixty healthy male Wistar rats were randomly divided into five groups: injury group,control group,sucralfate protective group,aluminium hydroxide protective group and aldioxa protective group.The three protective groups were treated with sucralfate,aluminium hydroxide and aldioxa tablets respectively before to induce gastric mucosal injury.Then the ulcer index,epithelial damage scoring,blood flow of gastric mucosa,the concentration of prostaglandin E2 and nitric oxide of gastric mucosa were measured,and the pathological changes on histological sections and ultrastructural sections of gastric mucosa were assessed under microscope or electron microscope.Results Compared with injury group,the ulcer index and epithelial damage scoring of gastric mucosa significantly decreased in aldioxa protective group(P=0.000,P=0.000),the blood flow of gastric mucosa significantly increased in aldioxa protective group(P=0.000),prostaglandin E2 and nitric oxide concentration of gastric mucosa significantly increased in aldioxa protective group(P=0.000,P=0.001).Conclusion The data revealed that aldioxa tablets had a significant protection effect on rats with acute gastric mucosa injury induced by ethanol,and the increase in blood flow,prostaglandin E2 and nitric oxide concentration maybe contribute to the protective effects.

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aldioxa片对阿司匹林致大鼠胃粘膜损伤的保护作用

目的研究aldioxa片对乙醇致大鼠胃粘膜损伤的保护作用，并探讨其可能的发病机制。方法健康雄性Wistar大鼠60只，随机分为5组:损伤组、对照组、硫糖铝保护组、氢氧化铝保护组和aldioxa保护组。3个保护组在诱导胃粘膜损伤前分别给予硫硫钠、氢氧化铝和醛氧草片。测定胃溃疡指数、上皮损伤评分、胃黏膜血流量、胃黏膜前列腺素E2和一氧化氮浓度，并在显微镜或电镜下观察胃黏膜组织切片和超微结构切片的病理变化。结果与损伤组比较，aldioxa保护组胃粘膜溃疡指数和上皮损伤评分显著降低(P=0.000,P=0.000)， aldioxa保护组胃黏膜血流量显著增加(P=0.000)， aldioxa保护组胃黏膜前列腺素E2和一氧化氮浓度显著升高(P=0.000,P=0.001)。结论aldioxa片对乙醇致急性胃黏膜损伤大鼠具有明显的保护作用，其作用机制可能与血流量、前列腺素E2和一氧化氮浓度的增加有关。

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来源期刊

胃肠病学和肝病学杂志

自引率

0.00%

发文量

7976

期刊介绍： Chinese Journal of Gastroenterology and Hepatology is a digestive academic journal sponsored by Zhengzhou University. It is open to submissions from home and abroad. The journal was founded in 1992 and officially approved in 1993. It has won the "Second Prize of Henan Province Excellent Science and Technology Journal". It was published quarterly from 1992 to 2002, bimonthly from 2003 to 2007, and monthly from 2008 to date. Since 2002, it has been included in the statistical source journals of scientific and technological papers of the Ministry of Science and Technology (core journals of the Ministry of Science and Technology). The purpose of publishing is to focus on improvement, while paying attention to popularization, striving to achieve popularization and improvement at the same time, following the principle of "improvement as the guide, improvement on the basis of popularization", to guide and promote the development of disciplines. In the publishing process, we pay attention to the advancement, readability, applicability, innovation, orientation, timeliness and policy of the content, and strive to achieve the standardization of editing and publishing.