Effects of soybean, selenium and spirulina on hemoglobin of rats intoxicated with fluorine and aluminium

Q3 Medicine

中华地方病学杂志 Pub Date : 2010-07-20 DOI:10.3760/CMA.J.ISSN.1000-4955.2010.04.009

Mo Fei, Qu Wei, X. Shu-hua, Yu Mao-juan, Tu Fei

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Abstract

Objective To observe the effects of soybean,selenium and spirulina on hemoglobin(Hb)of rats intoxicated with fluorine and aluminiums.Methods According to body weight,84 SD rats were randomly divided into control group,high aluminum group,high fluorine group,high fluorine-aluminum group,high fluorine-aluminium intoxicated rats strengthened with soybean group,high fluorine-aluminium intoxicated rats strengthened with selenium group and high fluorine-aluminium intoxicated rats strengthened with spirulina group,12 in each group.Rats in the control group and the high aluminum group were fed with feed containing 5.2 mg/kg of fluorine and 6.8 mg/kg of aluminum.In other groups,fluorine wag 106 mg/Kg and aluminum 19.7 mg/kg.Fluorine and aluminum concentration in the drinking water of the control group and the high fluorine group were 0.69 mg/L and 0.20 mg/L,respectively.In other groups' drinking water,these values were 0.69 mg/L and 90.2 mg/L,respectively.Ninety days later,Hb concentration of the whole blood was tested.Results Hb concentration of the control group,the high aluminum group,the high fluorine group,and the high fluorine-aluminum group were (160.8±6.3),(142.2±15.9),(156.1±4.9)and(145.2±6.2)g/L,respectively.Fluorine had an effect on the concentration of Hb(F=29.56,P 0.05).Conclusions High-dose fluorine could cause varied decrease in the concentration of Hb.However,aluminum has neitherantagonistic effect nor synergistic effect on the Hb of fluorotic Rat.Soybean,selenium and Spirulina show a trend to increase fluorotic rat's Hb,but they has no evident antagonistic effect. Key words: Soy beans; Selenium; Spindina; Fluorine; Aluminum; Hemoglobins

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大豆、硒和螺旋藻对氟、铝中毒大鼠血红蛋白的影响

目的观察大豆、硒和螺旋藻对氟、铝中毒大鼠血红蛋白(Hb)的影响。方法84只SD大鼠按体重随机分为对照组、高铝组、高氟组、高氟铝组、大豆强化高氟铝中毒大鼠、硒强化高氟铝中毒大鼠和螺旋藻强化高氟铝中毒大鼠，每组12只。对照组和高铝组分别饲喂含氟5.2 mg/kg、含铝6.8 mg/kg的饲料。在其他组中，氟为106毫克/公斤，铝为19.7毫克/公斤。对照组和高氟组饮用水氟、铝浓度分别为0.69 mg/L和0.20 mg/L。在其他组的饮用水中，这些值分别为0.69 mg/L和90.2 mg/L。90天后，检测全血Hb浓度。结果对照组、高铝组、高氟组和高氟铝组的Hb浓度分别为(160.8±6.3)、(142.2±15.9)、(156.1±4.9)和(145.2±6.2)g/L。氟对Hb浓度有影响(F=29.56, p0.05)。结论高剂量氟可引起Hb浓度不同程度的降低。铝对氟化大鼠Hb无拮抗作用，也无增效作用。大豆、硒和螺旋藻均有增加氟中毒大鼠Hb的趋势，但无明显的拮抗作用。关键词:大豆;硒;Spindina;氟;铝;血红蛋白

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来源期刊

中华地方病学杂志我国对人类健康危害特别严重的地方性疾病：克山病、大骨节病、碘缺乏病、地方性氟中毒、地方性砷中毒、鼠疫、布鲁氏菌病、寄生虫、新冠肺炎等疾病，同时还报道多发性自然疫源性疾病。

CiteScore

1.60

自引率

0.00%

发文量

8714

期刊介绍： The Chinese Journal of Endemiology covers predominantly endemic diseases threatening health of the people in the areas affected by the diseases including Keshan disease, Kaschin-Beck Disease, iodine deficiency disorders, endemic fluorosis, endemic arsenism, plague, epidemic hemorrhagic fever, brucellosis, parasite diseases and the diseases related to local natural and socioeconomic conditions; and reports researches in the basic science, etiology, epidemiology, clinical practice, control as well as multidisciplinary studies on the diseases.