Based on Microglial Polarization and Autophagy Activity After Intracerebral Hemorrhage Exploring the Anti-Injury-Promoting Repair Effect of Traditional Chinese Medicine Intervention Research Progress of Dual Action Mechanism

Abstract

Intracerebral hemorrhage is a common emergency in neurology. After the onset, primary and secondary injuries are formed, resulting in severe neurological deficits and brain damage. In response to this injury, the brain activates self-repair mechanisms such as microglia polarization and autophagy activity, aiming to maintain the homeostasis of the central nervous system by inhibiting injury and promoting repair. However, this endogenous repair has certain limitations. Therefore, exogenous intervention to promote the body to inhibit damage and promote repair is particularly important. In recent years, the treatment of cerebral hemorrhage with traditional Chinese medicine has received extensive attention due to its multi-target, multi-path, and multi-link action characteristics. To explore the dual mechanism of TCM intervention in promoting the body to inhibit damage and promote repair after cerebral hemorrhage will help to further clarify and improve the clinical efficacy of TCM in the treatment of cerebral hemorrhage.