Vasotoxic Effects of Anticancer Therapy: a Review of Current Data

IF 0.3 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Rational Pharmacotherapy in Cardiology Pub Date : 2023-05-12 DOI:10.20996/1819-6446-2023-03-03

Y. Vasyuk, E. Shupenina, A. G. Nosova, E. Novosel, D. Vyzhigin

引用次数: 0

Abstract

Cardiovascular and oncological diseases are the leading causes of adult death in the world. Despite proven efficacy, anticancer drugs can cause severe cardiovascular complications. Recently, data have appeared on the possible vasotoxic effects of chemotherapy drugs, which can manifest themselves as the progression of arterial hypertension and atherosclerosis, the development of myocardial ischemia and acute coronary syndrome, the formation of venous and arterial thrombosis. The key mechanism for the development of vasotoxicity is endothelial dysfunction, and anticancer drugs can also affect the processes of thrombosis. The review presents the results of 12 selected observational retro- and prospective studies involving cancer patients receiving presumably vasotoxic therapy. Data on the frequency of occurrence and possibilities for the prevention of vasotoxicity are presented.

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抗癌治疗的血管毒性作用:对当前数据的回顾

心血管和肿瘤疾病是世界上成年人死亡的主要原因。尽管抗癌药物已被证明有效，但它可能导致严重的心血管并发症。近年来，有资料显示化疗药物可能存在血管毒性作用，表现为动脉高血压和动脉粥样硬化的进展，心肌缺血和急性冠状动脉综合征的发展，静脉和动脉血栓的形成。血管毒性发展的关键机制是内皮功能障碍，抗癌药物也可以影响血栓形成的过程。本综述介绍了12项选择性观察性回顾性和前瞻性研究的结果，这些研究涉及可能接受血管毒性治疗的癌症患者。资料的发生频率和预防血管毒性的可能性提出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rational Pharmacotherapy in Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.00

自引率

50.00%

发文量

审稿时长

6 weeks

期刊介绍： The primary goals of the Journal are consolidation of information on scientific and practical achievements in pharmacotherapy and prevention of cardiovascular diseases and continuing education of cardiologists and internists. The scientific concept of the edition suggests the publication of information on current achievements in cardiology, the results of national and international clinical trials. The Journal publishes original articles on the results of clinical trials designed to study the effectiveness and safety of drugs, analysis of clinical practice and its compliance with national and international recommendations, expert s’ opinions on a wide range of cardiology issues, associated conditions and clinical pharmacology. There is a heading “Preventive cardiology and public health” in the Journal to stimulate research interest in this highly demanded area. Memories of the outstanding people in medicine including cardiology, which are of great interest to historians of medicine, are published in "Our Mentors” heading.